The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

Hye In Jang, Payton Stevens, Tianyan Gao, Emilia Galperin

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Leucine-rich repeat-containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and disease. We discuss Shoc2 and Erbin in the context of their multiple known interacting partners in various cellular processes and summarize often unexpected functions of these proteins through analysis of their roles in human pathologies. We also review these LRR scaffold proteins as promising therapeutic targets and biomarkers with potential application across various pathologies.

Original languageEnglish
Pages (from-to)721-739
Number of pages19
JournalFEBS Journal
Volume288
Issue number3
DOIs
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 Federation of European Biochemical Societies

Keywords

  • Erbin
  • Leucine-rich repeats
  • Shoc2
  • cancer
  • congenital disease
  • scaffold proteins
  • signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease'. Together they form a unique fingerprint.

Cite this