The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

Hye In Jang; Payton Stevens; Tianyan Gao; Emilia Galperin

doi:10.1111/febs.15450

The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

Hye In Jang
, Payton Stevens
, Tianyan Gao
, Emilia Galperin

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Leucine-rich repeat-containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and disease. We discuss Shoc2 and Erbin in the context of their multiple known interacting partners in various cellular processes and summarize often unexpected functions of these proteins through analysis of their roles in human pathologies. We also review these LRR scaffold proteins as promising therapeutic targets and biomarkers with potential application across various pathologies.

Original language	English
Pages (from-to)	721-739
Number of pages	19
Journal	FEBS Journal
Volume	288
Issue number	3
DOIs	https://doi.org/10.1111/febs.15450
State	Published - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 Federation of European Biochemical Societies

Funding

We thank Dr. Louis Hersh and members of our laboratories for critical reading of the manuscript. This project was supported by grants from the National Institute of General Medical Sciences (GM113087 and R35 GM136295 to EG), the American Cancer Society (RSG‐14‐172‐01‐CSM to EG), and National Cancer Institute (CA133429 and CA208343 to TG). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute of Health.

Funders	Funder number
American Cancer Society	RSG‐14‐172‐01‐CSM
National Childhood Cancer Registry – National Cancer Institute	CA208343, CA133429
National Institute of General Medical Sciences	R35GM136295, GM113087

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Erbin
Leucine-rich repeats
Shoc2
cancer
congenital disease
scaffold proteins
signaling

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1111/febs.15450

Cite this

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title = "The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease",

abstract = "Leucine-rich repeat-containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and disease. We discuss Shoc2 and Erbin in the context of their multiple known interacting partners in various cellular processes and summarize often unexpected functions of these proteins through analysis of their roles in human pathologies. We also review these LRR scaffold proteins as promising therapeutic targets and biomarkers with potential application across various pathologies.",

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note = "Publisher Copyright: {\textcopyright} 2020 Federation of European Biochemical Societies",

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doi = "10.1111/febs.15450",

language = "English",

volume = "288",

pages = "721--739",

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AU - Stevens, Payton

AU - Gao, Tianyan

AU - Galperin, Emilia

PY - 2021/2

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AB - Leucine-rich repeat-containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and disease. We discuss Shoc2 and Erbin in the context of their multiple known interacting partners in various cellular processes and summarize often unexpected functions of these proteins through analysis of their roles in human pathologies. We also review these LRR scaffold proteins as promising therapeutic targets and biomarkers with potential application across various pathologies.

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KW - Leucine-rich repeats

KW - Shoc2

KW - cancer

KW - congenital disease

KW - scaffold proteins

KW - signaling

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DO - 10.1111/febs.15450

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AN - SCOPUS:85087607935

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SP - 721

EP - 739

JO - FEBS Journal

JF - FEBS Journal

IS - 3

ER -

The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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