The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

Gulay Asci; Ercan Ok; Recep Savas; Mehmet Ozkahya; Soner Duman; Huseyin Toz; Meral Kayikcioglu; Adam J. Branscum; Marie Claude Monier-Faugere; Johann Herberth; Hartmut H. Malluche

doi:10.1093/ndt/gfq491

The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

Gulay Asci, Ercan Ok, Recep Savas, Mehmet Ozkahya, Soner Duman, Huseyin Toz, Meral Kayikcioglu, Adam J. Branscum, Marie Claude Monier-Faugere, Johann Herberth, Hartmut H. Malluche

Internal Medicine

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Background: Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).Methods. In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.

Original language	English
Pages (from-to)	1010-1015
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	26
Issue number	3
DOIs	https://doi.org/10.1093/ndt/gfq491
State	Published - Mar 2011

Bibliographical note

Funding Information:
Acknowledgements. Fresenius Medical Care supported this study. FMC have not been involved in any way in the study design, data management or manuscript preparation. Data from this study were presented at the XLIV Congress of the European Renal Association–European Dialysis and Transplant Association; June 24 through 27, 2007; Barcelona, Spain. We thank Ebru Sevinc, MD; Fatih Kırcelli, MD; and Mumtaz Yilmaz, MD for the support in performing bone biopsies and Timur Kose for the statistical advice. The study was supported by the Dean’s Clinical Research Scholar Program, University of Kentucky, no. 1012112710 (to J.H.), by NIH RO1 DK080770-01 (to H.H.M.) and by the Kentucky Nephrology Research Trust (to M-C.M-F.). We thank Guodong Wang, MD, Richard Wheaton and Julia Van Willigen for their technical support.

Keywords

bone turnover
bone volume
coronary calcifications
dialysis
renal osteodystrophy

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndt/gfq491

Cite this

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title = "The link between bone and coronary calcifications in CKD-5 patients on haemodialysis",

abstract = "Background: Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).Methods. In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.",

keywords = "bone turnover, bone volume, coronary calcifications, dialysis, renal osteodystrophy",

author = "Gulay Asci and Ercan Ok and Recep Savas and Mehmet Ozkahya and Soner Duman and Huseyin Toz and Meral Kayikcioglu and Branscum, {Adam J.} and Monier-Faugere, {Marie Claude} and Johann Herberth and Malluche, {Hartmut H.}",

note = "Funding Information: Acknowledgements. Fresenius Medical Care supported this study. FMC have not been involved in any way in the study design, data management or manuscript preparation. Data from this study were presented at the XLIV Congress of the European Renal Association–European Dialysis and Transplant Association; June 24 through 27, 2007; Barcelona, Spain. We thank Ebru Sevinc, MD; Fatih Kırcelli, MD; and Mumtaz Yilmaz, MD for the support in performing bone biopsies and Timur Kose for the statistical advice. The study was supported by the Dean{\textquoteright}s Clinical Research Scholar Program, University of Kentucky, no. 1012112710 (to J.H.), by NIH RO1 DK080770-01 (to H.H.M.) and by the Kentucky Nephrology Research Trust (to M-C.M-F.). We thank Guodong Wang, MD, Richard Wheaton and Julia Van Willigen for their technical support.",

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T1 - The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

AU - Asci, Gulay

AU - Ok, Ercan

AU - Savas, Recep

AU - Ozkahya, Mehmet

AU - Duman, Soner

AU - Toz, Huseyin

AU - Kayikcioglu, Meral

AU - Branscum, Adam J.

AU - Monier-Faugere, Marie Claude

AU - Herberth, Johann

AU - Malluche, Hartmut H.

N1 - Funding Information: Acknowledgements. Fresenius Medical Care supported this study. FMC have not been involved in any way in the study design, data management or manuscript preparation. Data from this study were presented at the XLIV Congress of the European Renal Association–European Dialysis and Transplant Association; June 24 through 27, 2007; Barcelona, Spain. We thank Ebru Sevinc, MD; Fatih Kırcelli, MD; and Mumtaz Yilmaz, MD for the support in performing bone biopsies and Timur Kose for the statistical advice. The study was supported by the Dean’s Clinical Research Scholar Program, University of Kentucky, no. 1012112710 (to J.H.), by NIH RO1 DK080770-01 (to H.H.M.) and by the Kentucky Nephrology Research Trust (to M-C.M-F.). We thank Guodong Wang, MD, Richard Wheaton and Julia Van Willigen for their technical support.

PY - 2011/3

Y1 - 2011/3

N2 - Background: Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).Methods. In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.

AB - Background: Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).Methods. In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.

KW - bone turnover

KW - bone volume

KW - coronary calcifications

KW - dialysis

KW - renal osteodystrophy

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The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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