The Lyme disease spirochete persists in nature through cycles between ticks and vertebrates. Although the spirochete interacts with numerous, distinct tissues and environmental conditions during its infectious cycle, Borrelia burgdorferi appears to possess a limited ability to sense its external environment. This apparent paradox is being resolved through detailed investigations of the molecular mechanisms through which B. burgdorferi controls production of virulence-associated factors such as the Erp outer surface proteins. The results have led to development of a model for how B. burgdorferi controls expression of its diverse proteins, wherein physiological and metabolic states that are unique to specific points in the infectious cycle trigger changes in gene and protein expression levels.
|Journal||Current Opinion in Microbiology|
|State||Published - Aug 2023|
Bibliographical noteFunding Information:
Dedicated to the memory of Christina R. Savage, Ph.D., a beloved friend and colleague. My thanks to the many people who have contributed to the studies described in this review. Special thanks to Andrew Krusenstjerna for modeling B. burgdorferi DnaA and BpaB. Research in our laboratory is currently funded by National Institutes of Health ( NIH ) grants R01AI144126, 3R01AI144126-03S1 , and R21AI147139 . Images were produced with Biorender.com.
© 2023 The Authors
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases