The Lyme disease spirochete, Borrelia burgdorferi, as a model vector-borne pathogen: insights on regulation of gene and protein expression

Brian Stevenson

doi:10.1016/j.mib.2023.102332

The Lyme disease spirochete, Borrelia burgdorferi, as a model vector-borne pathogen: insights on regulation of gene and protein expression

Research output: Contribution to journal › Review article › peer-review

Abstract

The Lyme disease spirochete persists in nature through cycles between ticks and vertebrates. Although the spirochete interacts with numerous, distinct tissues and environmental conditions during its infectious cycle, Borrelia burgdorferi appears to possess a limited ability to sense its external environment. This apparent paradox is being resolved through detailed investigations of the molecular mechanisms through which B. burgdorferi controls production of virulence-associated factors such as the Erp outer surface proteins. The results have led to development of a model for how B. burgdorferi controls expression of its diverse proteins, wherein physiological and metabolic states that are unique to specific points in the infectious cycle trigger changes in gene and protein expression levels.

Original language	English
Article number	102332
Journal	Current Opinion in Microbiology
Volume	74
DOIs	https://doi.org/10.1016/j.mib.2023.102332
State	Published - Aug 2023

Bibliographical note

Funding Information:
Dedicated to the memory of Christina R. Savage, Ph.D., a beloved friend and colleague. My thanks to the many people who have contributed to the studies described in this review. Special thanks to Andrew Krusenstjerna for modeling B. burgdorferi DnaA and BpaB. Research in our laboratory is currently funded by National Institutes of Health ( NIH ) grants R01AI144126, 3R01AI144126-03S1 , and R21AI147139 . Images were produced with Biorender.com.

Publisher Copyright:
© 2023 The Authors

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mib.2023.102332

Cite this

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The Lyme disease spirochete, Borrelia burgdorferi, as a model vector-borne pathogen: insights on regulation of gene and protein expression

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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