Abstract
In the thymus, a diverse and polymorphic T-cell repertoire is generated by random recombination of discrete T-cell receptor (TCR)-αβ gene segments. This repertoire is then shaped by intrathymic selection events to generate a peripheral T-cell pool of self-MHC restricted, non-autoaggressive T cells. It has long been postulated that some optimal level of TCR diversity allows efficient protection against pathogens. This article focuses on several recent advances that address the required diversity for the generation of an optimal immune response.
| Original language | English |
|---|---|
| Pages (from-to) | 123-132 |
| Number of pages | 10 |
| Journal | Nature Reviews Immunology |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2004 |
Funding
We wish to thank D. Parker and S. Murray (OHSU) for critical perusing of the manuscript. Our work is supported by the United States Public Health Service and the National Institutes of Health.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| National Childhood Cancer Registry – National Cancer Institute | R01CA086803 |
| U.S. Public Health Service |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Fingerprint
Dive into the research topics of 'The many important facets of T-cell repertoire diversity'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver