The microRNA world: Small is mighty

Peter Nelson; Marianthi Kiriakidou; Anup Sharma; Elsa Maniataki; Zissimos Mourelatos

doi:10.1016/j.tibs.2003.08.005

The microRNA world: Small is mighty

Peter Nelson, Marianthi Kiriakidou, Anup Sharma, Elsa Maniataki, Zissimos Mourelatos

Research output: Contribution to journal › Review article › peer-review

275 Citations (SciVal)

Abstract

A new paradigm of RNA-directed gene expression regulation has emerged recently, profound in scope but arresting in the apparent simplicity of its core mechanism. Cells express numerous small (∼22 nucleotide) RNAs that act as specificity determinants to direct destruction or translational repression of their mRNA targets. These small RNAs arise from processing of double-stranded RNA by the Dicer nuclease and incorporate with proteins that belong to the Argonaute family. Small RNAs might also target and silence homologous DNA sequences. The immense potential of small RNAs as controllers of gene networks is just beginning to unfold.

Original language	English
Pages (from-to)	534-540
Number of pages	7
Journal	Trends in Biochemical Sciences
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.tibs.2003.08.005
State	Published - Oct 2003

Bibliographical note

Funding Information:
We apologize to those whose work could not be cited because of space limitations. Supported by NIH grants to P.N. (5T32-AG00255), M.K. (5T32-AR07442) and Z.M. (NS02199) and by a University of Pennsylvania Genomics Institute award to Z.M.

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2003.08.005

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AU - Maniataki, Elsa

AU - Mourelatos, Zissimos

N1 - Funding Information: We apologize to those whose work could not be cited because of space limitations. Supported by NIH grants to P.N. (5T32-AG00255), M.K. (5T32-AR07442) and Z.M. (NS02199) and by a University of Pennsylvania Genomics Institute award to Z.M.

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AB - A new paradigm of RNA-directed gene expression regulation has emerged recently, profound in scope but arresting in the apparent simplicity of its core mechanism. Cells express numerous small (∼22 nucleotide) RNAs that act as specificity determinants to direct destruction or translational repression of their mRNA targets. These small RNAs arise from processing of double-stranded RNA by the Dicer nuclease and incorporate with proteins that belong to the Argonaute family. Small RNAs might also target and silence homologous DNA sequences. The immense potential of small RNAs as controllers of gene networks is just beginning to unfold.

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The microRNA world: Small is mighty

Abstract

Bibliographical note

ASJC Scopus subject areas

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