The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S. Knopman; Samantha Budd Haeberlein; Maria C. Carrillo; James A. Hendrix; Geoff Kerchner; Richard Margolin; Paul Maruff; David S. Miller; Gary Tong; Maria B. Tome; Melissa E. Murray; Peter T. Nelson; Mary Sano; Niklas Mattsson; David L. Sultzer; Thomas J. Montine; Clifford R. Jack; Hartmuth Kolb; Ronald C. Petersen; Prashanthi Vemuri; Megan Zoschg Canniere; Julie A. Schneider; Susan M. Resnick; Gary Romano; Argonde Corien van Harten; David A. Wolk; Lisa J. Bain; Eric Siemers

doi:10.1016/j.jalz.2018.03.002

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S. Knopman, Samantha Budd Haeberlein, Maria C. Carrillo, James A. Hendrix, Geoff Kerchner, Richard Margolin, Paul Maruff, David S. Miller, Gary Tong, Maria B. Tome, Melissa E. Murray, Peter T. Nelson, Mary Sano, Niklas Mattsson, David L. Sultzer, Thomas J. Montine, Clifford R. Jack, Hartmuth Kolb, Ronald C. Petersen, Prashanthi VemuriMegan Zoschg Canniere, Julie A. Schneider, Susan M. Resnick, Gary Romano, Argonde Corien van Harten, David A. Wolk, Lisa J. Bain, Eric Siemers

Research output: Contribution to journal › Short survey › peer-review

102 Scopus citations

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Original language	English
Pages (from-to)	563-575
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.jalz.2018.03.002
State	Published - Apr 2018

Bibliographical note

Publisher Copyright:
© 2018 the Alzheimer's Association

Funding

Funders	Funder number
National Institute on Aging	ZIAAG000185

Keywords

Alzheimer's disease
Amyloid
Biomarkers
Clinical trials
Neurodegeneration
Tau

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jalz.2018.03.002

Cite this

Knopman, D. S., Haeberlein, S. B., Carrillo, M. C., Hendrix, J. A., Kerchner, G., Margolin, R., Maruff, P., Miller, D. S., Tong, G., Tome, M. B., Murray, M. E., Nelson, P. T., Sano, M., Mattsson, N., Sultzer, D. L., Montine, T. J., Jack, C. R., Kolb, H., Petersen, R. C., ... Siemers, E. (2018). The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable. Alzheimer's and Dementia, 14(4), 563-575. https://doi.org/10.1016/j.jalz.2018.03.002

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title = "The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable",

abstract = "The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.",

keywords = "Alzheimer's disease, Amyloid, Biomarkers, Clinical trials, Neurodegeneration, Tau",

author = "Knopman, {David S.} and Haeberlein, {Samantha Budd} and Carrillo, {Maria C.} and Hendrix, {James A.} and Geoff Kerchner and Richard Margolin and Paul Maruff and Miller, {David S.} and Gary Tong and Tome, {Maria B.} and Murray, {Melissa E.} and Nelson, {Peter T.} and Mary Sano and Niklas Mattsson and Sultzer, {David L.} and Montine, {Thomas J.} and Jack, {Clifford R.} and Hartmuth Kolb and Petersen, {Ronald C.} and Prashanthi Vemuri and Canniere, {Megan Zoschg} and Schneider, {Julie A.} and Resnick, {Susan M.} and Gary Romano and {van Harten}, {Argonde Corien} and Wolk, {David A.} and Bain, {Lisa J.} and Eric Siemers",

note = "Publisher Copyright: {\textcopyright} 2018 the Alzheimer's Association",

year = "2018",

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doi = "10.1016/j.jalz.2018.03.002",

language = "English",

volume = "14",

pages = "563--575",

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Knopman, DS, Haeberlein, SB, Carrillo, MC, Hendrix, JA, Kerchner, G, Margolin, R, Maruff, P, Miller, DS, Tong, G, Tome, MB, Murray, ME, Nelson, PT, Sano, M, Mattsson, N, Sultzer, DL, Montine, TJ, Jack, CR, Kolb, H, Petersen, RC, Vemuri, P, Canniere, MZ, Schneider, JA, Resnick, SM, Romano, G, van Harten, AC, Wolk, DA, Bain, LJ & Siemers, E 2018, 'The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable', Alzheimer's and Dementia, vol. 14, no. 4, pp. 563-575. https://doi.org/10.1016/j.jalz.2018.03.002

TY - JOUR

T1 - The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease

T2 - Perspectives from the Research Roundtable

AU - Knopman, David S.

AU - Haeberlein, Samantha Budd

AU - Carrillo, Maria C.

AU - Hendrix, James A.

AU - Kerchner, Geoff

AU - Margolin, Richard

AU - Maruff, Paul

AU - Miller, David S.

AU - Tong, Gary

AU - Tome, Maria B.

AU - Murray, Melissa E.

AU - Nelson, Peter T.

AU - Sano, Mary

AU - Mattsson, Niklas

AU - Sultzer, David L.

AU - Montine, Thomas J.

AU - Jack, Clifford R.

AU - Kolb, Hartmuth

AU - Petersen, Ronald C.

AU - Vemuri, Prashanthi

AU - Canniere, Megan Zoschg

AU - Schneider, Julie A.

AU - Resnick, Susan M.

AU - Romano, Gary

AU - van Harten, Argonde Corien

AU - Wolk, David A.

AU - Bain, Lisa J.

AU - Siemers, Eric

PY - 2018/4

Y1 - 2018/4

N2 - The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

AB - The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

KW - Alzheimer's disease

KW - Amyloid

KW - Biomarkers

KW - Clinical trials

KW - Neurodegeneration

KW - Tau

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DO - 10.1016/j.jalz.2018.03.002

M3 - Short survey

C2 - 29653607

AN - SCOPUS:85044929982

SN - 1552-5260

VL - 14

SP - 563

EP - 575

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 4

ER -

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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