The nature and identification of quantitative trait loci: A community's view

Oduola Abiola; Joe M. Angel; Philip Avner; Alexander A. Bachmanov; John K. Belknap; Beth Bennett; Elizabeth P. Blankenhorn; David A. Blizard; Valerie Bolivar; Gudrun A. Brockmann; Kari J. Buck; Jean Francois Bureau; William L. Casley; Elissa J. Chesler; James M. Cheverud; Gary A. Churchill; Melloni Cook; John C. Crabbe; Wim E. Crusio; Ariel Darvasi; Gerald de Haan; Peter Demant; R. W. Doerge; Rosemary W. Elliott; Charles R. Farber; Lorraine Flaherty; Jonathan Flint; Howard Gershenfeld; John P. Gibson; Jing Gu; Weikuan Gu; Heinz Himmelbauer; Robert Hitzemann; Hui Chen Hsu; Kent Hunter; Fuad A. Iraqi; Ritsert C. Jansen; Thomas E. Johnson; Byron C. Jones; Gerd Kempermann; Frank Lammert; Lu Lu; Kenneth F. Manly; Douglas B. Matthews; Juan F. Medrano; Margarete Mehrabian; Guy Mittleman; Beverly A. Mock; Jeffrey S. Mogil; Xavier Montagutelli; Grant Morahan; John D. Mountz; Hiroki Nagase; Richard S. Nowakowski; Bruce F. O'Hara; Alexander V. Osadchuk; Beverly Paigen; Abraham A. Palmer; Jeremy L. Peirce; Daniel Pomp; Michael Rosemann; Glenn D. Rosen; Leonard C. Schalkwyk; Ze'ev Seltzer; Stephen Settle; Kazuhiro Shimomura; Siming Shou; James M. Sikela; Linda D. Siracusa; Jimmy L. Spearow; Cory Teuscher; David W. Threadgill; Linda A. Toth; Ayo A. Toye; Csaba Vadasz; Gary Van Zant; Edward Wakeland; Robert W. Williams; Huang Ge Zhang; Fei Zou

doi:10.1038/nrg1206

The nature and identification of quantitative trait loci: A community's view

Oduola Abiola, Joe M. Angel, Philip Avner, Alexander A. Bachmanov, John K. Belknap, Beth Bennett, Elizabeth P. Blankenhorn, David A. Blizard, Valerie Bolivar, Gudrun A. Brockmann, Kari J. Buck, Jean Francois Bureau, William L. Casley, Elissa J. Chesler, James M. Cheverud, Gary A. Churchill, Melloni Cook, John C. Crabbe, Wim E. Crusio, Ariel DarvasiGerald de Haan, Peter Demant, R. W. Doerge, Rosemary W. Elliott, Charles R. Farber, Lorraine Flaherty, Jonathan Flint, Howard Gershenfeld, John P. Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui Chen Hsu, Kent Hunter, Fuad A. Iraqi, Ritsert C. Jansen, Thomas E. Johnson, Byron C. Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F. Manly, Douglas B. Matthews, Juan F. Medrano, Margarete Mehrabian, Guy Mittleman, Beverly A. Mock, Jeffrey S. Mogil, Xavier Montagutelli, Grant Morahan, John D. Mountz, Hiroki Nagase, Richard S. Nowakowski, Bruce F. O'Hara, Alexander V. Osadchuk, Beverly Paigen, Abraham A. Palmer, Jeremy L. Peirce, Daniel Pomp, Michael Rosemann, Glenn D. Rosen, Leonard C. Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M. Sikela, Linda D. Siracusa, Jimmy L. Spearow, Cory Teuscher, David W. Threadgill, Linda A. Toth, Ayo A. Toye, Csaba Vadasz, Gary Van Zant, Edward Wakeland, Robert W. Williams, Huang Ge Zhang, Fei Zou

Research output: Contribution to journal › Review article › peer-review

375 Scopus citations

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Original language	English
Pages (from-to)	911-916
Number of pages	6
Journal	Nature Reviews Genetics
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nrg1206
State	Published - Nov 2003

Funding

Funders	Funder number
National Institute on Deafness and Other Communication Disorders	R03DC003854
National Institute on Deafness and Other Communication Disorders

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1038/nrg1206

Cite this

Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J. F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., Crusio, W. E., ... Zou, F. (2003). The nature and identification of quantitative trait loci: A community's view. Nature Reviews Genetics, 4(11), 911-916. https://doi.org/10.1038/nrg1206

@article{dfb9ce9bf33f462a9574a319ad95c18b,

title = "The nature and identification of quantitative trait loci: A community's view",

abstract = "This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?",

author = "Oduola Abiola and Angel, {Joe M.} and Philip Avner and Bachmanov, {Alexander A.} and Belknap, {John K.} and Beth Bennett and Blankenhorn, {Elizabeth P.} and Blizard, {David A.} and Valerie Bolivar and Brockmann, {Gudrun A.} and Buck, {Kari J.} and Bureau, {Jean Francois} and Casley, {William L.} and Chesler, {Elissa J.} and Cheverud, {James M.} and Churchill, {Gary A.} and Melloni Cook and Crabbe, {John C.} and Crusio, {Wim E.} and Ariel Darvasi and {de Haan}, Gerald and Peter Demant and Doerge, {R. W.} and Elliott, {Rosemary W.} and Farber, {Charles R.} and Lorraine Flaherty and Jonathan Flint and Howard Gershenfeld and Gibson, {John P.} and Jing Gu and Weikuan Gu and Heinz Himmelbauer and Robert Hitzemann and Hsu, {Hui Chen} and Kent Hunter and Iraqi, {Fuad A.} and Jansen, {Ritsert C.} and Johnson, {Thomas E.} and Jones, {Byron C.} and Gerd Kempermann and Frank Lammert and Lu Lu and Manly, {Kenneth F.} and Matthews, {Douglas B.} and Medrano, {Juan F.} and Margarete Mehrabian and Guy Mittleman and Mock, {Beverly A.} and Mogil, {Jeffrey S.} and Xavier Montagutelli and Grant Morahan and Mountz, {John D.} and Hiroki Nagase and Nowakowski, {Richard S.} and O'Hara, {Bruce F.} and Osadchuk, {Alexander V.} and Beverly Paigen and Palmer, {Abraham A.} and Peirce, {Jeremy L.} and Daniel Pomp and Michael Rosemann and Rosen, {Glenn D.} and Schalkwyk, {Leonard C.} and Ze'ev Seltzer and Stephen Settle and Kazuhiro Shimomura and Siming Shou and Sikela, {James M.} and Siracusa, {Linda D.} and Spearow, {Jimmy L.} and Cory Teuscher and Threadgill, {David W.} and Toth, {Linda A.} and Toye, {Ayo A.} and Csaba Vadasz and {Van Zant}, Gary and Edward Wakeland and Williams, {Robert W.} and Zhang, {Huang Ge} and Fei Zou",

year = "2003",

month = nov,

doi = "10.1038/nrg1206",

language = "English",

volume = "4",

pages = "911--916",

number = "11",

}

Abiola, O, Angel, JM, Avner, P, Bachmanov, AA, Belknap, JK, Bennett, B, Blankenhorn, EP, Blizard, DA, Bolivar, V, Brockmann, GA, Buck, KJ, Bureau, JF, Casley, WL, Chesler, EJ, Cheverud, JM, Churchill, GA, Cook, M, Crabbe, JC, Crusio, WE, Darvasi, A, de Haan, G, Demant, P, Doerge, RW, Elliott, RW, Farber, CR, Flaherty, L, Flint, J, Gershenfeld, H, Gibson, JP, Gu, J, Gu, W, Himmelbauer, H, Hitzemann, R, Hsu, HC, Hunter, K, Iraqi, FA, Jansen, RC, Johnson, TE, Jones, BC, Kempermann, G, Lammert, F, Lu, L, Manly, KF, Matthews, DB, Medrano, JF, Mehrabian, M, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, X, Morahan, G, Mountz, JD, Nagase, H, Nowakowski, RS, O'Hara, BF, Osadchuk, AV, Paigen, B, Palmer, AA, Peirce, JL, Pomp, D, Rosemann, M, Rosen, GD, Schalkwyk, LC, Seltzer, Z, Settle, S, Shimomura, K, Shou, S, Sikela, JM, Siracusa, LD, Spearow, JL, Teuscher, C, Threadgill, DW, Toth, LA, Toye, AA, Vadasz, C, Van Zant, G, Wakeland, E, Williams, RW, Zhang, HG & Zou, F 2003, 'The nature and identification of quantitative trait loci: A community's view', Nature Reviews Genetics, vol. 4, no. 11, pp. 911-916. https://doi.org/10.1038/nrg1206

TY - JOUR

T1 - The nature and identification of quantitative trait loci

T2 - A community's view

AU - Abiola, Oduola

AU - Angel, Joe M.

AU - Avner, Philip

AU - Bachmanov, Alexander A.

AU - Belknap, John K.

AU - Bennett, Beth

AU - Blankenhorn, Elizabeth P.

AU - Blizard, David A.

AU - Bolivar, Valerie

AU - Brockmann, Gudrun A.

AU - Buck, Kari J.

AU - Bureau, Jean Francois

AU - Casley, William L.

AU - Chesler, Elissa J.

AU - Cheverud, James M.

AU - Churchill, Gary A.

AU - Cook, Melloni

AU - Crabbe, John C.

AU - Crusio, Wim E.

AU - Darvasi, Ariel

AU - de Haan, Gerald

AU - Demant, Peter

AU - Doerge, R. W.

AU - Elliott, Rosemary W.

AU - Farber, Charles R.

AU - Flaherty, Lorraine

AU - Flint, Jonathan

AU - Gershenfeld, Howard

AU - Gibson, John P.

AU - Gu, Jing

AU - Gu, Weikuan

AU - Himmelbauer, Heinz

AU - Hitzemann, Robert

AU - Hsu, Hui Chen

AU - Hunter, Kent

AU - Iraqi, Fuad A.

AU - Jansen, Ritsert C.

AU - Johnson, Thomas E.

AU - Jones, Byron C.

AU - Kempermann, Gerd

AU - Lammert, Frank

AU - Lu, Lu

AU - Manly, Kenneth F.

AU - Matthews, Douglas B.

AU - Medrano, Juan F.

AU - Mehrabian, Margarete

AU - Mittleman, Guy

AU - Mock, Beverly A.

AU - Mogil, Jeffrey S.

AU - Montagutelli, Xavier

AU - Morahan, Grant

AU - Mountz, John D.

AU - Nagase, Hiroki

AU - Nowakowski, Richard S.

AU - O'Hara, Bruce F.

AU - Osadchuk, Alexander V.

AU - Paigen, Beverly

AU - Palmer, Abraham A.

AU - Peirce, Jeremy L.

AU - Pomp, Daniel

AU - Rosemann, Michael

AU - Rosen, Glenn D.

AU - Schalkwyk, Leonard C.

AU - Seltzer, Ze'ev

AU - Settle, Stephen

AU - Shimomura, Kazuhiro

AU - Shou, Siming

AU - Sikela, James M.

AU - Siracusa, Linda D.

AU - Spearow, Jimmy L.

AU - Teuscher, Cory

AU - Threadgill, David W.

AU - Toth, Linda A.

AU - Toye, Ayo A.

AU - Vadasz, Csaba

AU - Van Zant, Gary

AU - Wakeland, Edward

AU - Williams, Robert W.

AU - Zhang, Huang Ge

AU - Zou, Fei

PY - 2003/11

Y1 - 2003/11

N2 - This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

AB - This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

UR - http://www.scopus.com/inward/record.url?scp=0242291131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242291131&partnerID=8YFLogxK

U2 - 10.1038/nrg1206

DO - 10.1038/nrg1206

M3 - Review article

C2 - 14634638

AN - SCOPUS:0242291131

SN - 1471-0056

VL - 4

SP - 911

EP - 916

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 11

ER -

The nature and identification of quantitative trait loci: A community's view

Abstract

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ASJC Scopus subject areas

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