After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.
|Number of pages||13|
|State||Published - Oct 1 2019|
Bibliographical noteFunding Information:
We would like to thank S. Baur, Ch. Schustetter, K. Stingl, and P. Meyer for their excellent technical assistance as well as G. Weirich and C. Delbridge for professional conduction of general and brain autopsy. We also thank J. A. Schroeder for his very helpful advice regarding the evaluation of ultrastructural tissue analysis. This work was partly supported by Grants from the German Federal Ministry of Education and Research within the research consortium “ZooBoCo” (Grant no. 01KI1722A).
© 2019, The Author(s).
- Borna disease virus (BoDV-1)
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
- Cellular and Molecular Neuroscience