TY - JOUR
T1 - The neuropathology of fatal encephalomyelitis in human Borna virus infection
AU - Liesche, Friederike
AU - Ruf, Viktoria
AU - Zoubaa, Saida
AU - Kaletka, Gwendolyn
AU - Rosati, Marco
AU - Rubbenstroth, Dennis
AU - Herden, Christiane
AU - Goehring, Lutz
AU - Wunderlich, Silke
AU - Wachter, Miguel Frederic
AU - Rieder, Georg
AU - Lichtmannegger, Ines
AU - Permanetter, Willibald
AU - Heckmann, Josef G.
AU - Angstwurm, Klemens
AU - Neumann, Bernhard
AU - Märkl, Bruno
AU - Haschka, Stefan
AU - Niller, Hans Helmut
AU - Schmidt, Barbara
AU - Jantsch, Jonathan
AU - Brochhausen, Christoph
AU - Schlottau, Kore
AU - Ebinger, Arnt
AU - Hemmer, Bernhard
AU - Riemenschneider, Markus J.
AU - Herms, Jochen
AU - Beer, Martin
AU - Matiasek, Kaspar
AU - Schlegel, Jürgen
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/10/1
Y1 - 2019/10/1
N2 - After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.
AB - After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.
KW - Borna disease virus (BoDV-1)
KW - Bornavirus
KW - Encephalitis
KW - Virus
KW - Zoonosis
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U2 - 10.1007/s00401-019-02047-3
DO - 10.1007/s00401-019-02047-3
M3 - Article
C2 - 31346692
AN - SCOPUS:85069748072
SN - 0001-6322
VL - 138
SP - 653
EP - 665
JO - Acta Neuropathologica
JF - Acta Neuropathologica
IS - 4
ER -
