Gene recombination experiments are not only useful for the generation of novel hybrid natural products, but can also be helpful in intercepting unstable biosynthetic intermediates to allow conclusions to be made about their structures. Premithramycinone H (1), a biologically active hybrid which results from a mixture of mithramycin and tetracenomycin biosynthetic genes, is a good example of this strategy.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Feb 18 2000|
- Antitumor agents
- Hybrid natural products
ASJC Scopus subject areas
- Chemistry (all)