TY - JOUR
T1 - The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin
AU - Lombó, Felipe
AU - Künzel, Eva
AU - Prado, Laura
AU - Braña, Alfredo F.
AU - Bindseil, Kai U.
AU - Frevert, Jürgen
AU - Bearden, Dan
AU - Méndez, Carmen
AU - Salas, José A.
AU - Rohr, Jürgen
PY - 2000/2/18
Y1 - 2000/2/18
N2 - Gene recombination experiments are not only useful for the generation of novel hybrid natural products, but can also be helpful in intercepting unstable biosynthetic intermediates to allow conclusions to be made about their structures. Premithramycinone H (1), a biologically active hybrid which results from a mixture of mithramycin and tetracenomycin biosynthetic genes, is a good example of this strategy.
AB - Gene recombination experiments are not only useful for the generation of novel hybrid natural products, but can also be helpful in intercepting unstable biosynthetic intermediates to allow conclusions to be made about their structures. Premithramycinone H (1), a biologically active hybrid which results from a mixture of mithramycin and tetracenomycin biosynthetic genes, is a good example of this strategy.
KW - Antibiotics
KW - Antitumor agents
KW - Biosynthesis
KW - Hybrid natural products
KW - Polyketides
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U2 - 10.1002/(SICI)1521-3773(20000218)39:4<796::AID-ANIE796>3.0.CO;2-N
DO - 10.1002/(SICI)1521-3773(20000218)39:4<796::AID-ANIE796>3.0.CO;2-N
M3 - Article
AN - SCOPUS:0034681535
SN - 1433-7851
VL - 39
SP - 796
EP - 799
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 4
ER -