Abstract
The current study examined the effect of the novel nicotinic acetylcholine receptor antagonist, N,N′-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), on nicotine-induced dopamine metabolism in rat nucleus accumbens, striatum and medial prefrontal cortex. Acute nicotine (0.5 mg/kg, s.c.) produced an increase in the content of dihydroxyphenylacetic acid (DOPAC) in nucleus accumbens, but not in striatum or medial prefrontal cortex. Pretreatment with bPiDDB (1 or 3 mg/kg, s.c.) dose-dependently inhibited the nicotine-induced increase in DOPAC content in nucleus accumbens. These results indicate that bPiDDB inhibits the nicotine-induced increase in DOPAC in reward-relevant brain region targeting nicotinic acetylcholine receptors.
Original language | English |
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Pages (from-to) | 103-105 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 601 |
Issue number | 1-3 |
DOIs | |
State | Published - Dec 28 2008 |
Bibliographical note
Funding Information:This work was supported by USPHS grant U19 DA17548. For purposes of full disclosure, the University of Kentucky holds patents on bPiDDB and a potential royalty stream to L.P.D. and P.A.C. may occur consistent with University of Kentucky policy.
Keywords
- DOPAC
- Dopamine metabolism
- HPLC
- Nicotinic receptor
- Nucleus accumbens
- bPiDDB
ASJC Scopus subject areas
- Pharmacology