The Nuclear Tyrosine Kinase Rak Associates with the Retinoblastoma Protein pRb

Rolf J. Craven, William G. Cance, Edison T. Liu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Rak is a nuclear tyrosine kinase containing Src homology 2 and 3 domains at its NH2 terminus. We report here that the retinoblastoma tumor susceptibility gene product pRb associates with Rak in vivo and in vitro. Rak binds to the A/B pocket region of pRb, a region that is frequently mutated in human cancer, during the G, and S phases of the cell cycle. Furthermore, Rak expression is elevated in G1, and transfection of Rak into NIH 3T3 cells results in a significant decrease in the number of emerging colonies. Thus, Rak is a tyrosine kinase with growth suppressing activity that may function, in part, through its interaction with pRb.

Original languageEnglish
Pages (from-to)3964-3968
Number of pages5
JournalCancer Research
Volume55
Issue number18
StatePublished - Sep 15 1995

Funding

FundersFunder number
National Childhood Cancer Registry – National Cancer InstituteK08CA001625

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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