The oxidative ring cleavage in jadomycin biosynthesis: A multistep oxygenation cascade in a biosynthetic black box

Uwe Rix, Chenchen Wang, Yihua Chen, Fredilyn M. Lipata, Lily L.Remsing Rix, Lisa M. Greenwell, Leo C. Vining, Keqian Yang, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Backbone-breaking oxygenase clusters. Inactivation of the oxygenase-encoding genes jadH and jadG and structure elucidation of novel accumulation products illustrate the essential interactions within the biosynthetic protein complex that govern the oxygenation cascade leading to the cleavage of the angucycline backbone during jadomycin biosynthesis by Streptomyces venezuelae. These results also allow the elucidation of the dehydration sequence (shown) that yields the aromatic ring A of the jadomycin scaffold.

Original languageEnglish
Pages (from-to)838-845
Number of pages8
JournalChemBioChem
Volume6
Issue number5
DOIs
StatePublished - May 2005

Keywords

  • Biosynthesis
  • Cleavage reactions
  • Dehydratases
  • Oxygenases
  • Polyketides
  • Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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