TY - JOUR
T1 - The pharmacokinetics of intravenous and oral torsemide in patients with chronic renal insufficiency
AU - Gehr, Todd W.B.
AU - Rudy, David W.
AU - Matzke, Gary R.
AU - Kramer, William G.
AU - Sica, Domenic A.
AU - Brater, D. Craig
PY - 1994/7
Y1 - 1994/7
N2 - Torsemide is a diuretic that acts in the thick ascending limb of the loop of Henle. Unlike furosemide, it undergoes substantial hepatic elimination and should not accumulate in patients with renal insufficiency. Therefore the pharmacokinetics of intravenous and oral torsemide and its metabolites were investigated in patients with chronic renal insufficiency. Two groups of 24 patients stratified by creatinine clearance (30 to 60 ml/min and <30 ml/min) were studied in two separate randomized dose escalating crossover studies, one using intravenous torsemide and the other using oral torsemide. The pharmacokinetics of both intravenous and oral torsemide were linear over the dosage range studied. Absolute bioavailability was essentially 100%. Renal clearance was greatly diminished and correlated with renal function. Total plasma clearance and half‐life were not related to renal function and were found to be similar to those of healthy subjects. The substantial nonrenal clearance of torsemide prevents accumulation in patients with chronic renal insufficiency. Clinical Pharmacology and Therapeutics (1994) 56, 31–38; doi:
AB - Torsemide is a diuretic that acts in the thick ascending limb of the loop of Henle. Unlike furosemide, it undergoes substantial hepatic elimination and should not accumulate in patients with renal insufficiency. Therefore the pharmacokinetics of intravenous and oral torsemide and its metabolites were investigated in patients with chronic renal insufficiency. Two groups of 24 patients stratified by creatinine clearance (30 to 60 ml/min and <30 ml/min) were studied in two separate randomized dose escalating crossover studies, one using intravenous torsemide and the other using oral torsemide. The pharmacokinetics of both intravenous and oral torsemide were linear over the dosage range studied. Absolute bioavailability was essentially 100%. Renal clearance was greatly diminished and correlated with renal function. Total plasma clearance and half‐life were not related to renal function and were found to be similar to those of healthy subjects. The substantial nonrenal clearance of torsemide prevents accumulation in patients with chronic renal insufficiency. Clinical Pharmacology and Therapeutics (1994) 56, 31–38; doi:
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U2 - 10.1038/clpt.1994.98
DO - 10.1038/clpt.1994.98
M3 - Article
C2 - 8033493
AN - SCOPUS:0028064340
SN - 0009-9236
VL - 56
SP - 31
EP - 38
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 1
ER -