Abstract
An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.
| Original language | English |
|---|---|
| Pages (from-to) | 1931-1942 |
| Number of pages | 12 |
| Journal | Synthetic Communications |
| Volume | 34 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2004 |
Bibliographical note
Funding Information:This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.
Funding
This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.
| Funders | Funder number |
|---|---|
| National Institute of Health National Institute of Minority and Health Disparities Loan Repayment Program | DA13519, DA00399 |
Keywords
- Aldol condensation
- CNS agents
- THF
- Tropane analogs
ASJC Scopus subject areas
- Organic Chemistry