TY - JOUR
T1 - The presence of luteinized unruptured follicle syndrome and altered folliculogenesis in rats with surgically induced endometriosis
AU - Moon, Carol Eve M.
AU - Bertero, Maria C.
AU - Curry, Thomas E.
AU - London, Steven N.
AU - Muse, Ken N.
AU - Sharpe, Kathy L.
AU - Vernon, Michael W.
PY - 1993/9
Y1 - 1993/9
N2 - Objective: Our purpose was to determine in the rat model whether endometriosis could influence ovarian function by altering oocyte release or folliculogenesis. Study design: We histologically examined the ovaries of reproductively cycling rats with (n = 16) and without (n = 10) surgically induced endometriosis. The rats in these two groups were further subdivided into unilaterally ovariectomized or ovarian-intact groups. Serial sections of ovaries were examined, and follicular development and frequency of luteinized unruptured follicles were determined. Results: A significant tenfold increase in the number of luteinized unruptured follicles was observed in the ovaries from rats with endometriosis (2.7 per rat) compared with unoperated and sham-operated control groups (overall mean 0.26 per rat, p < 0.05). Additionally, ovaries from unilateral ovariectomized animals with endometriosis contained four times as many luteinized unruptured follicles (four per rat) as did the ovaries from bilaterally ovarian-intact rats with endometriosis (1.40 per rat, p < 0.01). Fewer follicles were present in rats with endometriosis (180 follicles per ovary) than in control rats (231 follicles per ovary, p < 0.05). Conclusion: In the rat model the presence of ectopic endometrium is associated with an increased frequency of luteinized unruptured follicles and altered follicular development.
AB - Objective: Our purpose was to determine in the rat model whether endometriosis could influence ovarian function by altering oocyte release or folliculogenesis. Study design: We histologically examined the ovaries of reproductively cycling rats with (n = 16) and without (n = 10) surgically induced endometriosis. The rats in these two groups were further subdivided into unilaterally ovariectomized or ovarian-intact groups. Serial sections of ovaries were examined, and follicular development and frequency of luteinized unruptured follicles were determined. Results: A significant tenfold increase in the number of luteinized unruptured follicles was observed in the ovaries from rats with endometriosis (2.7 per rat) compared with unoperated and sham-operated control groups (overall mean 0.26 per rat, p < 0.05). Additionally, ovaries from unilateral ovariectomized animals with endometriosis contained four times as many luteinized unruptured follicles (four per rat) as did the ovaries from bilaterally ovarian-intact rats with endometriosis (1.40 per rat, p < 0.01). Fewer follicles were present in rats with endometriosis (180 follicles per ovary) than in control rats (231 follicles per ovary, p < 0.05). Conclusion: In the rat model the presence of ectopic endometrium is associated with an increased frequency of luteinized unruptured follicles and altered follicular development.
KW - Endometriosis
KW - folliculogenesis
KW - luteinized unruptured follicle syndrome
KW - ovulatory dysfunction
KW - rat endometriosis model
UR - https://www.scopus.com/pages/publications/0027453993
UR - https://www.scopus.com/pages/publications/0027453993#tab=citedBy
U2 - 10.1016/0002-9378(93)90642-V
DO - 10.1016/0002-9378(93)90642-V
M3 - Article
C2 - 8372879
AN - SCOPUS:0027453993
SN - 0002-9378
VL - 169
SP - 676
EP - 682
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -