The prevention and treatment of metabolic syndrome and high-risk obesity

Behzad Molavi, Neda Rasouli, Philip A. Kern

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


PURPOSE OF REVIEW: The prevalence of obesity is increasing at an alarming rate, and the obesity epidemic is driving the epidemic in type 2 diabetes. High-risk obesity is characterized by abdominal obesity with evidence of abnormal glucose and lipid metabolism, and a state of heightened inflammation. RECENT FINDINGS: With increasing body weight, lipid accumulation occurs not only in adipose tissue, but in other organs as well. This 'lipotoxicity' in liver, muscle, islets, and elsewhere may account for many of the features of the metabolic syndrome. Adipose tissue produces many proteins, some of which are inflammatory cytokines, and others of which are antiinflammatory or which improve insulin sensitivity. SUMMARY: The treatment of obesity requires the identification of the high-risk patient, and the institution of lifestyle measures with a long-term outlook, and an avoidance of heavily marketed fads. Current research will likely lead to improved medications in the future.

Original languageEnglish
Pages (from-to)479-485
Number of pages7
JournalCurrent Opinion in Cardiology
Issue number5
StatePublished - Sep 2006


  • High-risk obesity
  • Lipid
  • Metabolic syndrome
  • Prevention
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'The prevention and treatment of metabolic syndrome and high-risk obesity'. Together they form a unique fingerprint.

Cite this