TY - JOUR
T1 - The rapid development of functional tolerance to ethanol by mice
AU - GRIEVE, SUSAN J.
AU - LITTLETON, JOHN M.
PY - 1979/9
Y1 - 1979/9
N2 - A method is described in which the development of tolerance to ethanol in individual mice can be measured during the inhalation of ethanol vapour. This method has been used with two behavioural end‐points, loss of righting reflex and loss of rotarod performance. It demonstrates that, in the adult male, TO Swiss mouse, peak tolerance, in which approximately 2 × the original effective blood ethanol concentration is required to produce the behavioural end‐point, can develop in 3–5 h. After this time the ability of the animals to perform normally in the presence of continued high concentrations of ethanol in blood begins to fall. The results are discussed in relation to current concepts of tolerance to central nervous system depressant drugs. 1979 Royal Pharmaceutical Society of Great Britain
AB - A method is described in which the development of tolerance to ethanol in individual mice can be measured during the inhalation of ethanol vapour. This method has been used with two behavioural end‐points, loss of righting reflex and loss of rotarod performance. It demonstrates that, in the adult male, TO Swiss mouse, peak tolerance, in which approximately 2 × the original effective blood ethanol concentration is required to produce the behavioural end‐point, can develop in 3–5 h. After this time the ability of the animals to perform normally in the presence of continued high concentrations of ethanol in blood begins to fall. The results are discussed in relation to current concepts of tolerance to central nervous system depressant drugs. 1979 Royal Pharmaceutical Society of Great Britain
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U2 - 10.1111/j.2042-7158.1979.tb13601.x
DO - 10.1111/j.2042-7158.1979.tb13601.x
M3 - Article
C2 - 41062
AN - SCOPUS:0018646972
SN - 0022-3573
VL - 31
SP - 605
EP - 610
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 1
ER -