The regulation of herpes simplex virus-specific CTL induction by suppressor cells

D. W. Horohov, R. N. Moore, B. T. Rouse

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The incubation of herpes simplex virus (HSV) immune murine splenocytes with HSV antigens induced suppressor cells which inhibited HSV-specific cytotoxic T lymphocyte (CTL) induction. The cell mediating the suppression was identified as a Thy 1+ Lyt2+ I-J+ cell. The induction of this suppressor cell required the participation of at least three leukocyte populations. That is, depleting the cultures of either Lyt 1+ or Lyt 2+ splenocytes resulted in a failure to induce suppressor cell activity. Likewise the removal of macrophage like antigen-presenting cells (APC), in particular I-A- I-J+ APC, abolished suppressor-cell induction. Though the Lyt 2+ I-J+ cells had to be provided by HSV-immune mice, both the APC and the lyht 1+ cells could be provided by HSV-naive mice. Though the induction of the suppressor cell was virus specific, its action was nonspecific as evidenced by the suppression of influenza-specific CTL induction. The implication of our results for the understanding and manipulation of herpesvirus disease is briefly discussed.

Original languageEnglish
Pages (from-to)55-68
Number of pages14
JournalViral Immunology
Issue number1
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology


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