The relationship between clinical trial network protocol involvement and quality of substance use disorder treatment

Amanda J. Abraham, Hannah K. Knudsen, Paul M. Roman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The National Institute on Drug Abuse's Clinical Trials Network (CTN) is a practice-based research network that partners academic researchers with community based substance use disorder (SUD) treatment programs designed primarily to conduct effectiveness trials of promising interventions. A secondary goal of the CTN is to widely disseminate results of these trials and thus improve the quality of SUD treatment in the US. Drawing on data from 156 CTN programs, this study examines the association between involvement in CTN protocols and overall treatment quality measured by a comprehensive index of 35 treatment services. Negative binomial regression models show that treatment programs participating in a greater number of CTN protocols had significantly higher levels of treatment quality, an association that held after controlling for key organizational characteristics. These findings contribute to the growing body of research on the role of practice-based research networks in promoting health care quality.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Substance Abuse Treatment
Issue number2
StatePublished - Feb 2014

Bibliographical note

Funding Information:
Data collection for these analyses was funded by Research Grant Number R01DA14482 from the National Institute on Drug Abuse (NIDA) of the National Institutes of Health . Additional support was received from Research Grant Number R01AA015974 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and Research Grant Number R37DA013110 from NIDA . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


  • Clinical trials network
  • Practice-based research network
  • Quality of care
  • Substance use disorders
  • Treatment

ASJC Scopus subject areas

  • Psychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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