The Relationship Between Dental Agenesis and Maxillary Hypoplasia in Patients With Cleft Lip and Palate

Lindsay E. Janes, Mohamed Bazina, Sherif S. Morcos, Angelica Ukaigwe, Manish Valiathan, Ronald Jacobson, Arun K. Gosain

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Both dental agenesis and maxillary growth restriction are well-recognized sequelae in patients with unilateral cleft lip and palate, but their etiology remains controversial. The aim of this study was to evaluate the relationship between hypodontia and maxillary volume. A retrospective review of patients age 6 to 9 with Veau III (unilateral) cleft palate who underwent Cone Beam Computer Tomography in preparation for alveolar bone grafting at 2 major Children's Hospitals between 2010 and 2016 was conducted and serial panoramic radiographs were reviewed. Thirty-eight patients were identified that met inclusion criteria and had adequate imaging. Group 1 ("poor growers") consisted of the bottom 50% of Sella-Nasion-A point minus Sella-Nasion-B point (ANB) angles and Group 2 ("good growers") consisted of the top 50% of ANB angles. Group 1 had a significantly higher mean number of missing teeth (1.58±0.28 missing teeth) compared to Group 2 (0.74±0.23 missing teeth), and significantly lower maxillary volume (12.88±0.61cm3versus 15.24±0.88cm3, respectively). The severity of maxillary hypoplasia in cleft patients increases with increased dental agenesis. These data indicate that intrinsic factors play a significant role in maxillary growth restriction in cleft patients, independent of the sequelae of surgical intervention.

Original languageEnglish
Pages (from-to)2012-2015
Number of pages4
JournalJournal of Craniofacial Surgery
Issue number6
StatePublished - Sep 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.


  • Cleft palate
  • dental agenesis
  • hypodontia
  • maxillary retrusion

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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