Aims: The aim of the study was to determine whether the trajectory of learning and memory is modified according to an interaction between midlife or late life alcohol consumption status and the presence of one or more APOE e4 alleles. Methods: This was a secondary analysis of cognitive, genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort. Results: Light and moderate alcohol consumption during late life was associated with greater decline in learning and memory among APOE e4 carriers, whereas light and moderate alcohol consumption was associated with an increase in learning and memory among non-APOE e4 carriers. There was not a significant interaction between midlife alcohol consumption status and APOE e4 on the trajectory of learning and memory. Conclusion: Light to moderate alcohol consumption during late life may protect against a decline in learning and memory for non-APOE e4 allele carriers, but not for older adults who carry one or more APOE e4 alleles.
|Number of pages||6|
|Journal||Alcohol and Alcoholism|
|State||Published - Jan 2014|
Bibliographical noteFunding Information:
Acknowledgments — The Framingham Heart Study is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with Boston University. The opinions and conclusions are solely of the authors and do not reflect the FHS or NHLBI.
Funding — This work was supported by the National Institutes of Health, D.W.F. [5P30AG028383-07 and 8P20GM103436-12] and F.Z. [1K01DA031764]
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Psychiatry and Mental health