The revised national Alzheimer's coordinating center's neuropathology form-available data and new analyses

Lilah M. Besser, Walter A. Kukull, Merilee A. Teylan, Eileen H. Bigio, Nigel J. Cairns, Julia K. Kofler, Thomas J. Montine, Julie A. Schneider, Peter T. Nelson

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Neuropathologic evaluation remains the gold standard for determining the presence and severity of aging-related neurodegenerative diseases. Researchers at U.S. Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs. Harmonization and sharing among the 39 current and past ADCs is promoted by the National Alzheimer's Coordinating Center (NACC), which collects, audits, and disburses ADC-derived data to investigators on request. The past decades have witnessed revised disease definitions paired with dramatic expansion in the granularity and multimodality of the collected data. The NACC database now includes cognitive test scores, comorbidities, drug history, neuroimaging, and links to genomics. Relatively, recent advances in the neuropathologic diagnoses of Alzheimer's disease, frontotemporal lobar degeneration (FTLD), and vascular contributions to cognitive impairment and dementia catalyzed a 2014 update to the NACC Neuropathology Form completed by all ADCs. New focal points include cerebrovascular disease (including arteriolosclerosis, microbleeds, and microinfarcts), hippocampal sclerosis, TDP-43, and FTLD. Here, we provide summary data and analyses to illustrate the potential for both hypothesis-testing and also generating new hypotheses using the NACC Neuropathology data set, which represents one of the largest multi-center databases of carefully curated neuropathologic information that is freely available to researchers worldwide.

Original languageEnglish
Pages (from-to)717-726
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume77
Issue number8
DOIs
StatePublished - Aug 1 2018

Bibliographical note

Publisher Copyright:
© 2018 American Association of Neuropathologists, Inc. All rights reserved.

Keywords

  • Lewy
  • MRI
  • Primary age-related tauopathy (PART)
  • Stroke
  • Subjective memory complaint (SMC)
  • Tauopathy

ASJC Scopus subject areas

  • General Medicine

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