The RGK family of GTP-binding proteins: Regulators of voltage-dependent calcium channels and cytoskeleton remodeling

Robert N. Correll, Chunyan Pang, Dana M. Niedowicz, Brian S. Finlin, Douglas A. Andres

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

RGK proteins constitute a novel subfamily of small Ras-related proteins that function as potent inhibitors of voltage-dependent (VDCC) Ca2+ channels and regulators of actin cytoskeletal dynamics. Within the larger Ras superfamily, RGK proteins have distinct regulatory and structural characteristics, including nonconservative amino acid substitutions within regions known to participate in nucleotide binding and hydrolysis and a C-terminal extension that contains conserved regulatory sites which control both subcellular localization and function. RGK GTPases interact with the VDCC β-subunit (CaVβ) and inhibit Rho/Rho kinase signaling to regulate VDCC activity and the cytoskeleton respectively. Binding of both calmodulin and 14-3-3 to RGK proteins, and regulation by phosphorylation controls cellular trafficking and the downstream signaling of RGK proteins, suggesting that a complex interplay between interacting protein factors and trafficking contribute to their regulation.

Original languageEnglish
Pages (from-to)292-300
Number of pages9
JournalCellular Signalling
Volume20
Issue number2
DOIs
StatePublished - Feb 2008

Bibliographical note

Funding Information:
We apologize to the scientists whose work was not cited due to space constraints. Research of the authors was supported by Public Health Service Grants HL072936 (to D.A.A.), a National Center for Research Resources grant P20 RR20171 (to D.A.A.), an American Diabetes Junior Faculty Award 7-05-JF-16 to (B.S.F.), and an NIH Interdisciplinary Cardiovascular Training Grant T32 HL072743 (to R.N.C.).

Keywords

  • Actin cytoskeleton
  • CaV1.2
  • Calcium
  • GTP-binding
  • Gem
  • Ion channel
  • Rad
  • Ras GTPase
  • Rem
  • Rem2
  • Signal transduction
  • VDCC

ASJC Scopus subject areas

  • Cell Biology

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