The effect of chlorethylclonidine on α1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.
|Number of pages||6|
|Journal||European Journal of Pharmacology|
|State||Published - May 16 1990|
Bibliographical noteFunding Information:
The work was supportedin part by Grants from the National Instituteso f Health (HL-38120), AmericanH eart AssociationK,e ntuckyA ffiliatea ndt heU niversitoyf Kentucky MedicalC enter.
- Receptor alkylation
- α-adrenoceptor subtypes
ASJC Scopus subject areas