The role of α1-adrenoceptor subtypes in the regulation of arterial blood pressure

Michael T. Piascik, Brent T. Butler, Terry A. Pruitt

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The effect of chlorethylclonidine on α1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalEuropean Journal of Pharmacology
Volume180
Issue number2-3
DOIs
StatePublished - May 16 1990

Bibliographical note

Funding Information:
The work was supportedin part by Grants from the National Instituteso f Health (HL-38120), AmericanH eart AssociationK,e ntuckyA ffiliatea ndt heU niversitoyf Kentucky MedicalC enter.

Keywords

  • (Receptors)
  • Chlorethylclonidine
  • Receptor alkylation
  • α-adrenoceptor subtypes
  • α-adrenoceptors

ASJC Scopus subject areas

  • Pharmacology

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