The role of α1-adrenoceptor subtypes in the regulation of arterial blood pressure

Michael T. Piascik; Brent T. Butler; Terry A. Pruitt

doi:10.1016/0014-2999(90)90327-3

The role of α₁-adrenoceptor subtypes in the regulation of arterial blood pressure

Michael T. Piascik
, Brent T. Butler
, Terry A. Pruitt

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of chlorethylclonidine on α₁-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α₁-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α₁-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.

Original language	English
Pages (from-to)	381-386
Number of pages	6
Journal	European Journal of Pharmacology
Volume	180
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90327-3
State	Published - May 16 1990

Bibliographical note

Funding Information:
The work was supportedin part by Grants from the National Instituteso f Health (HL-38120), AmericanH eart AssociationK,e ntuckyA ffiliatea ndt heU niversitoyf Kentucky MedicalC enter.

Funding

The work was supportedin part by Grants from the National Instituteso f Health (HL-38120), AmericanH eart AssociationK,e ntuckyA ffiliatea ndt heU niversitoyf Kentucky MedicalC enter.

Funders	Funder number
AmericanH eart AssociationK
National Instituteso f Health
National Heart, Lung, and Blood Institute (NHLBI)	R01HL038120

Keywords

(Receptors)
Chlorethylclonidine
Receptor alkylation
α-adrenoceptor subtypes
α-adrenoceptors

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(90)90327-3

Cite this

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title = "The role of α1-adrenoceptor subtypes in the regulation of arterial blood pressure",

abstract = "The effect of chlorethylclonidine on α1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.",

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author = "Piascik, \{Michael T.\} and Butler, \{Brent T.\} and Pruitt, \{Terry A.\}",

note = "Funding Information: The work was supportedin part by Grants from the National Instituteso f Health (HL-38120), AmericanH eart AssociationK,e ntuckyA ffiliatea ndt heU niversitoyf Kentucky MedicalC enter.",

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AB - The effect of chlorethylclonidine on α1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the α1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systematic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the α1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.

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