The Role of γ-Aminobutyric Acid in the Interoceptive Effects of Oral Δ9-Tetrahydrocannabinol in Humans

J. A. Lile, J. S. Fogel, T. H. Kelly

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

This chapter focuses on the involvement of δ-aminobutyric acid (ie, GABA) in the interoceptive effects of Δ9-tetrahydrocannabinol (ie, Δ9-THC) in humans. The interoceptive effects of drugs can be assessed using drug discrimination methodology, which is a selective means to examine neuropharmacological interactions between neurotransmitter systems. In humans trained to discriminate oral Δ9-THC, the GABA reuptake inhibitor tiagabine substituted for Δ9-THC, and enhanced the discriminative stimulus effects of Δ9-THC. The GABAB agonist baclofen, but not the GABAA positive allosteric modulator diazepam, also substituted for Δ9-THC, and enhanced the discriminative stimulus effects of Δ9-THC. The results from these clinical drug-discrimination studies disagree with preclinical data, suggesting that the neuropharmacological interactions between GABA and CB systems differ between human and nonhuman species. The studies reviewed here indicate that GABA, particularly the GABAB receptor subtype, plays a significant part in the interoceptive effects produced by Δ9-THC, and by extension cannabis, in humans.

Original languageEnglish
Title of host publicationHandbook of Cannabis and Related Pathologies
Subtitle of host publicationBiology, Pharmacology, Diagnosis, and Treatment
Pages770-778
Number of pages9
ISBN (Electronic)9780128008270
DOIs
StatePublished - Jan 24 2017

Keywords

  • Cannabis
  • Discriminative stimulus
  • Drug interactions
  • Drug-discrimination
  • GABA transporter
  • GABA
  • GABA
  • Interoceptive
  • Marijuana

ASJC Scopus subject areas

  • Medicine (all)
  • Neuroscience (all)

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