Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.
|Number of pages||14|
|Journal||Advanced Drug Delivery Reviews|
|State||Published - Jul 28 2001|
Bibliographical noteFunding Information:
This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).
- Cholera toxin
ASJC Scopus subject areas
- Pharmaceutical Science