The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking

Sergey Matveev, Xiangan Li, William Everson, Eric J. Smart

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.

Original languageEnglish
Pages (from-to)237-250
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume49
Issue number3
DOIs
StatePublished - Jul 28 2001

Bibliographical note

Funding Information:
This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).

Keywords

  • Cholera toxin
  • Cholesterol
  • Endocytosis
  • Potocytosis
  • Trafficking
  • Transcytosis

ASJC Scopus subject areas

  • Pharmaceutical Science

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