Abstract
Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.
| Original language | English |
|---|---|
| Pages (from-to) | 237-250 |
| Number of pages | 14 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 28 2001 |
Bibliographical note
Funding Information:This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).
Funding
This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | HL62844, HL64056 |
| National Institutes of Health (NIH) | |
| National Heart, Lung, and Blood Institute Family Blood Pressure Program | R01HL058475 |
| National Heart, Lung, and Blood Institute Family Blood Pressure Program |
Keywords
- Cholera toxin
- Cholesterol
- Endocytosis
- Potocytosis
- Trafficking
- Transcytosis
ASJC Scopus subject areas
- Pharmaceutical Science
