Autism spectrum disorder (ASD) comprises a heterogeneous range of neurodevelopmental conditions represented by symptoms including, communication and language deficits, repetitive, and restricted patterns of behavior and inadequate social interactions. Gamma-aminobutyric acid (GABA) is known to mediate I responses in the central nervous system by interacting with GABA signaling receptors. In this context, several recent investigations suggest that imbalances in the GABAergic neurotransmission system may be implicated in the development of ASD as well as several other neurodevelopmental disorders, including Fragile X syndrome (FXS) and Rett syndrome. This review initially expounds the functional role of the GABAergic system in the mature brain and during neurodevelopment. This will be followed by discussions concerning the impact of deficiencies in the system on ASD and the other above-mentioned neurodevelopment disorders. Finally, the connections between these deficiencies and behavioral features observed in the clinic will be considered.
|Number of pages||13|
|Journal||International Journal of Developmental Neuroscience|
|State||Published - Apr 1 2020|
Bibliographical noteFunding Information:
This study was supported by the National Natural Science Foundation of China (No. 81528023 and No.81671219).
© 2020 International Society for Development Neuroscience
- Fragile X syndrome
- I interneurons
- Rett syndrome
- autism spectrum disorder
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology