The Role of Glutamate Dysregulation in the Etiology of ADHD

P. E.A. Glaser, S. R. Batten, G. A. Gerhardt

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


In this chapter we review current data assessing the role of glutamate in the etiology of ADHD. A general introduction of ADHD and common comorbidities are briefly discussed. The glutamate system in general and its potential role in ADHD are thoroughly reviewed evaluating both preclinical and clinical data. The current ADHD treatments that act on the glutamate system, memantine and atomoxetine, are discussed. The chapter concludes with a discussion on the future of glutamatergic drugs in the treatment of ADHD.

Original languageEnglish
Title of host publicationGlutamate and Neuropsychiatric Disorders
Subtitle of host publicationCurrent and Emerging Treatments
Number of pages26
ISBN (Electronic)9783030874803
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2022.


  • ADHD
  • Brain energetics
  • Glutamate
  • Glutamatergic pharmacotherapies

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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