The role of hot plate and general environmental stimuli in morphine analgesic tolerance

Michael T. Bardo; Paul J. Wellman; Richard A. Hughes

doi:10.1016/0091-3057(81)90145-3

The role of hot plate and general environmental stimuli in morphine analgesic tolerance

Michael T. Bardo, Paul J. Wellman, Richard A. Hughes

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Rats given one injection of morphine (5 mg/kg) paired with a hot plate test displayed greater analgesic tolerance than rats given nine injections of morphine paired with a distinct room in which the hot plate apparatus was located. Hot plate stimuli, rather than general environmental stimuli, are prepotent in the acquisition of morphine analgesic tolerance assessed by the hot plate procedure.

Original language	English
Pages (from-to)	757-760
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90145-3
State	Published - May 1981

Keywords

Hot plate
Morphine analgesia
Morphine tolerance
Rat

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(81)90145-3

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title = "The role of hot plate and general environmental stimuli in morphine analgesic tolerance",

abstract = "Rats given one injection of morphine (5 mg/kg) paired with a hot plate test displayed greater analgesic tolerance than rats given nine injections of morphine paired with a distinct room in which the hot plate apparatus was located. Hot plate stimuli, rather than general environmental stimuli, are prepotent in the acquisition of morphine analgesic tolerance assessed by the hot plate procedure.",

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AB - Rats given one injection of morphine (5 mg/kg) paired with a hot plate test displayed greater analgesic tolerance than rats given nine injections of morphine paired with a distinct room in which the hot plate apparatus was located. Hot plate stimuli, rather than general environmental stimuli, are prepotent in the acquisition of morphine analgesic tolerance assessed by the hot plate procedure.

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KW - Morphine analgesia

KW - Morphine tolerance

KW - Rat

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The role of hot plate and general environmental stimuli in morphine analgesic tolerance

Abstract

Keywords

ASJC Scopus subject areas

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