The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks

Elana M. Gloger; Stephanie T. Judge; Rebecca G. Reed; Steven R. Presnell; Ahmad Al-Attar; Charles T. Lutz; Suzanne C. Segerstrom

doi:10.1016/j.bbih.2022.100512

The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks

Elana M. Gloger, Stephanie T. Judge, Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom

Research output: Contribution to journal › Article › peer-review

Abstract

Interferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8⁺ T cells, particularly CD28⁻and CD57⁺ subsets, which increase with age, reduce immune response, and increase chronic disease risk. The present study investigated the relationship between late-differentiated T cells (LDTC) and sociability in a longitudinal study of healthy aging. 139 older adults (M_age = 77.95, range 65–93; 58% female, 57% college educated, and 94% Caucasian) provided data at up to 10 occasions (M = 7). Social network size and diversity and cytomegalovirus (CMV) status were collected at every wave. Percentage of LDTC was measured at up to 4 waves and averaged for each participant. There were no significant main effects of LDTC or interactions between LDTC and time on social network size or diversity. Adjustment for baseline age, gender, and sensitivity analyses including CMV and imputed data did not change results. IFN-γ may not play a role in dictating social behavior in older adults. Alternately, LDTC may not have accurately represented circulating levels of IFN-γ. Future work should continue exploring IFN-γ and social behavior, particularly as it relates to age-related changes. The role of IFN-γ-producing, late-differentiated T cells in older adults’ social networks.

Original language	English
Article number	100512
Journal	Brain, Behavior, and Immunity - Health
Volume	25
DOIs	https://doi.org/10.1016/j.bbih.2022.100512
State	Published - Nov 2022

Bibliographical note

Funding Information:
This work was supported by the National Institute on Aging (K99/R00-AG056635 [RGR], R01-AG026307 [SCS], K02-AG033629 [SCS], P30-AG028383 ).

Funding Information:
The UK Flow Cytometry & Cell Sorting core facility is supported in part by the Office of the Vice President for Research , the Markey Cancer Center , and an NCI Center Core Support Grant ( P30 CA177558 ) to the University of Kentucky Markey Cancer Center.

Publisher Copyright:
© 2022 The Authors

ASJC Scopus subject areas

Nephrology

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10.1016/j.bbih.2022.100512

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title = "The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults{\textquoteright} social networks",

abstract = "Interferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8+ T cells, particularly CD28−and CD57+ subsets, which increase with age, reduce immune response, and increase chronic disease risk. The present study investigated the relationship between late-differentiated T cells (LDTC) and sociability in a longitudinal study of healthy aging. 139 older adults (Mage = 77.95, range 65–93; 58% female, 57% college educated, and 94% Caucasian) provided data at up to 10 occasions (M = 7). Social network size and diversity and cytomegalovirus (CMV) status were collected at every wave. Percentage of LDTC was measured at up to 4 waves and averaged for each participant. There were no significant main effects of LDTC or interactions between LDTC and time on social network size or diversity. Adjustment for baseline age, gender, and sensitivity analyses including CMV and imputed data did not change results. IFN-γ may not play a role in dictating social behavior in older adults. Alternately, LDTC may not have accurately represented circulating levels of IFN-γ. Future work should continue exploring IFN-γ and social behavior, particularly as it relates to age-related changes. The role of IFN-γ-producing, late-differentiated T cells in older adults{\textquoteright} social networks.",

author = "Gloger, {Elana M.} and Judge, {Stephanie T.} and Reed, {Rebecca G.} and Presnell, {Steven R.} and Ahmad Al-Attar and Lutz, {Charles T.} and Segerstrom, {Suzanne C.}",

note = "Funding Information: This work was supported by the National Institute on Aging (K99/R00-AG056635 [RGR], R01-AG026307 [SCS], K02-AG033629 [SCS], P30-AG028383 ). Funding Information: The UK Flow Cytometry & Cell Sorting core facility is supported in part by the Office of the Vice President for Research , the Markey Cancer Center , and an NCI Center Core Support Grant ( P30 CA177558 ) to the University of Kentucky Markey Cancer Center. Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Reed, Rebecca G.

AU - Presnell, Steven R.

AU - Al-Attar, Ahmad

AU - Lutz, Charles T.

AU - Segerstrom, Suzanne C.

N1 - Funding Information: This work was supported by the National Institute on Aging (K99/R00-AG056635 [RGR], R01-AG026307 [SCS], K02-AG033629 [SCS], P30-AG028383 ). Funding Information: The UK Flow Cytometry & Cell Sorting core facility is supported in part by the Office of the Vice President for Research , the Markey Cancer Center , and an NCI Center Core Support Grant ( P30 CA177558 ) to the University of Kentucky Markey Cancer Center. Publisher Copyright: © 2022 The Authors

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The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks

Abstract

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