The role of microglia in adult hippocampal neurogenesis

Carmelina Gemma, Adam D. Bachstetter

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations


Our view of microglia has dramatically changed in the last decade. From cells being "silent" in the healthy brain, microglia have emerged to be actively involved in several brain physiological functions including adult hippocampal neurogenesis, and cognitive and behavioral function. In light of recent discoveries revealing a role of microglia as important effectors of neuronal circuit reorganization, considerable attention has been focused on how microglia and hippocampal neurogenesis could be an interdependent phenomenon. In this review the role of microglia in the adult hippocampal neurogenesis under physiological condition is discussed.

Original languageEnglish
Article number229
JournalFrontiers in Cellular Neuroscience
Issue numberNOV
StatePublished - Nov 22 2013

Bibliographical note

Copyright 2014 Elsevier B.V., All rights reserved.


  • CX3CR1
  • Chemokines
  • Fractalkine
  • Microglia
  • Neurogenesis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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