The role of microRNAs in skeletal muscle health and disease

Tyler J. Kirby, Thomas Chaillou, John J. McCarthy

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Original languageEnglish
Pages (from-to)37-77
Number of pages41
JournalFrontiers in Bioscience - Landmark
Volume20
Issue number1
DOIs
StatePublished - Jan 15 2015

Bibliographical note

Publisher Copyright:
© 2015, Frontiers in Bioscience. All rights reserved.

Keywords

  • Atrophy
  • Exercise
  • Hypertrophy
  • Muscular dystrophy
  • MyomiR
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)

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