The role of microRNAs in skeletal muscle health and disease

Tyler J. Kirby; Thomas Chaillou; John J. McCarthy

doi:10.2741/4298

The role of microRNAs in skeletal muscle health and disease

Tyler J. Kirby, Thomas Chaillou, John J. McCarthy

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Original language	English
Pages (from-to)	37-77
Number of pages	41
Journal	Frontiers in Bioscience - Landmark
Volume	20
Issue number	1
DOIs	https://doi.org/10.2741/4298
State	Published - Jan 15 2015

Bibliographical note

Publisher Copyright:
© 2015, Frontiers in Bioscience. All rights reserved.

Keywords

Atrophy
Exercise
Hypertrophy
Muscular dystrophy
MyomiR
Review

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.2741/4298

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KW - Hypertrophy

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KW - MyomiR

KW - Review

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The role of microRNAs in skeletal muscle health and disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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