Abstract
Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.
| Original language | English |
|---|---|
| Pages (from-to) | 37-77 |
| Number of pages | 41 |
| Journal | Frontiers in Bioscience - Landmark |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 15 2015 |
Bibliographical note
Publisher Copyright:© 2015, Frontiers in Bioscience. All rights reserved.
Funding
| Funders | Funder number |
|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases | R01AR060701 |
Keywords
- Atrophy
- Exercise
- Hypertrophy
- Muscular dystrophy
- MyomiR
- Review
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
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