The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Elisabeth Conradt; Beau Abar; Stephen Sheinkopf; Barry Lester; Linda Lagasse; Ronald Seifer; Seetha Shankaran; Henrietta Bada-Ellzey; Charles Bauer; Toni Whitaker; Matt Hinckley; Jane Hammond; Rosemary Higgins

doi:10.1002/dev.21155

The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Elisabeth Conradt, Beau Abar, Stephen Sheinkopf, Barry Lester, Linda Lagasse, Ronald Seifer, Seetha Shankaran, Henrietta Bada-Ellzey, Charles Bauer, Toni Whitaker, Matt Hinckley, Jane Hammond, Rosemary Higgins

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

Original language	English
Pages (from-to)	821-835
Number of pages	15
Journal	Developmental Psychobiology
Volume	56
Issue number	4
DOIs	https://doi.org/10.1002/dev.21155
State	Published - May 1 2014

Bibliographical note

Publisher Copyright:
© 2013 Wiley Periodicals, Inc.

Keywords

allostatic load
early adversity
prenatal substance exposure
respiratory sinus arrhythmia

ASJC Scopus subject areas

Developmental and Educational Psychology
Developmental Neuroscience
Developmental Biology
Behavioral Neuroscience

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10.1002/dev.21155

Cite this

Conradt, E., Abar, B., Sheinkopf, S., Lester, B., Lagasse, L., Seifer, R., Shankaran, S., Bada-Ellzey, H., Bauer, C., Whitaker, T., Hinckley, M., Hammond, J., & Higgins, R. (2014). The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age. Developmental Psychobiology, 56(4), 821-835. https://doi.org/10.1002/dev.21155

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abstract = "We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.",

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Conradt, E, Abar, B, Sheinkopf, S, Lester, B, Lagasse, L, Seifer, R, Shankaran, S, Bada-Ellzey, H, Bauer, C, Whitaker, T, Hinckley, M, Hammond, J & Higgins, R 2014, 'The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age', Developmental Psychobiology, vol. 56, no. 4, pp. 821-835. https://doi.org/10.1002/dev.21155

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AU - Conradt, Elisabeth

AU - Abar, Beau

AU - Sheinkopf, Stephen

AU - Lester, Barry

AU - Lagasse, Linda

AU - Seifer, Ronald

AU - Shankaran, Seetha

AU - Bada-Ellzey, Henrietta

AU - Bauer, Charles

AU - Whitaker, Toni

AU - Hinckley, Matt

AU - Hammond, Jane

AU - Higgins, Rosemary

PY - 2014/5/1

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N2 - We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

AB - We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

KW - allostatic load

KW - early adversity

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The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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