The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Elisabeth Conradt; Beau Abar; Stephen Sheinkopf; Barry Lester; Linda Lagasse; Ronald Seifer; Seetha Shankaran; Henrietta Bada-Ellzey; Charles Bauer; Toni Whitaker; Matt Hinckley; Jane Hammond; Rosemary Higgins

doi:10.1002/dev.21155

The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Elisabeth Conradt
, Beau Abar
, Stephen Sheinkopf
, Barry Lester
, Linda Lagasse
, Ronald Seifer
, Seetha Shankaran
, Henrietta Bada-Ellzey
, Charles Bauer
, Toni Whitaker
, Matt Hinckley
, Jane Hammond
, Rosemary Higgins

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

Original language	English
Pages (from-to)	821-835
Number of pages	15
Journal	Developmental Psychobiology
Volume	56
Issue number	4
DOIs	https://doi.org/10.1002/dev.21155
State	Published - May 1 2014

Bibliographical note

Publisher Copyright:
© 2013 Wiley Periodicals, Inc.

Funding

Funders	Funder number
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Brown Center for the study of Children at Risk; Department of Psychiatry, Warren Alpert Medical School of Brown University. [email protected]	U10-DA-024117-01, U10-DA-024118-01, F32 DA032175, U10-DA-024119-01, U10-HD-21385, N01-HD-2-3159, U10-HD-21397, I10-DA-024128-06, U10-HD-2786, U10-HD-27904
National Institute on Drug Abuse	F32DA032175

Keywords

allostatic load
early adversity
prenatal substance exposure
respiratory sinus arrhythmia

ASJC Scopus subject areas

Developmental and Educational Psychology
Developmental Neuroscience
Developmental Biology
Behavioral Neuroscience

Access to Document

10.1002/dev.21155

Cite this

Conradt, E., Abar, B., Sheinkopf, S., Lester, B., Lagasse, L., Seifer, R., Shankaran, S., Bada-Ellzey, H., Bauer, C., Whitaker, T., Hinckley, M., Hammond, J., & Higgins, R. (2014). The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age. Developmental Psychobiology, 56(4), 821-835. https://doi.org/10.1002/dev.21155

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title = "The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age",

abstract = "We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.",

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author = "Elisabeth Conradt and Beau Abar and Stephen Sheinkopf and Barry Lester and Linda Lagasse and Ronald Seifer and Seetha Shankaran and Henrietta Bada-Ellzey and Charles Bauer and Toni Whitaker and Matt Hinckley and Jane Hammond and Rosemary Higgins",

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Conradt, E, Abar, B, Sheinkopf, S, Lester, B, Lagasse, L, Seifer, R, Shankaran, S, Bada-Ellzey, H, Bauer, C, Whitaker, T, Hinckley, M, Hammond, J & Higgins, R 2014, 'The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age', Developmental Psychobiology, vol. 56, no. 4, pp. 821-835. https://doi.org/10.1002/dev.21155

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T1 - The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

AU - Conradt, Elisabeth

AU - Abar, Beau

AU - Sheinkopf, Stephen

AU - Lester, Barry

AU - Lagasse, Linda

AU - Seifer, Ronald

AU - Shankaran, Seetha

AU - Bada-Ellzey, Henrietta

AU - Bauer, Charles

AU - Whitaker, Toni

AU - Hinckley, Matt

AU - Hammond, Jane

AU - Higgins, Rosemary

PY - 2014/5/1

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N2 - We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

AB - We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

KW - allostatic load

KW - early adversity

KW - prenatal substance exposure

KW - respiratory sinus arrhythmia

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The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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