The role of Src family kinases in the normal and neoplastic gastrointestinal tract

N. Banker; B. M. Evers; M. R. Hellmich; C. M. Townsend

doi:10.1016/s0960-7404(96)80023-5

The role of Src family kinases in the normal and neoplastic gastrointestinal tract

N. Banker, B. M. Evers, M. R. Hellmich, C. M. Townsend

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.

Original language	English
Pages (from-to)	201-210
Number of pages	10
Journal	Surgical Oncology
Volume	5
Issue number	5-6
DOIs	https://doi.org/10.1016/s0960-7404(96)80023-5
State	Published - 1996

Keywords

Differentiation
Gastrointestinal tract
Growth
Neoplasms
SH2
Src kinase

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s0960-7404(96)80023-5

Cite this

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title = "The role of Src family kinases in the normal and neoplastic gastrointestinal tract",

abstract = "Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.",

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T1 - The role of Src family kinases in the normal and neoplastic gastrointestinal tract

AU - Banker, N.

AU - Evers, B. M.

AU - Hellmich, M. R.

AU - Townsend, C. M.

PY - 1996

Y1 - 1996

N2 - Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.

AB - Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.

KW - Differentiation

KW - Gastrointestinal tract

KW - Growth

KW - Neoplasms

KW - SH2

KW - Src kinase

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DO - 10.1016/s0960-7404(96)80023-5

M3 - Review article

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AN - SCOPUS:0030440907

SN - 0960-7404

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JO - Surgical Oncology

JF - Surgical Oncology

IS - 5-6

ER -

The role of Src family kinases in the normal and neoplastic gastrointestinal tract

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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