Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers, and is known for its extremely poor prognosis. Because of the location and composition of the organ, early symptoms cannot be visualized as easily as in other solid tumors. In the past decades, researchers have been mostly working on the genetic and epigenetic alterations of the cancer cells themselves, and therapies on pancreatic cancer cells alone have failed to significantly improve patient outcome. With the identification of abundant tumor stromal responses, the focus of pancreatic cancer research has begun to change. Increasing evidence has proved that the tumor stroma, especially the cell components (such as pancreatic stellate cells, tumor-associated macrophages, mast cells etc.) plays a key role in the development of PDAC. In this review, we discuss the interactions between cancer cells and several important cell components of the tumor stroma, as well their role in tumor growth, migration, invasion, angiogenesis and immune recognition.
| Original language | English |
|---|---|
| Pages (from-to) | 1117-1124 |
| Number of pages | 8 |
| Journal | Anti-Cancer Agents in Medicinal Chemistry |
| Volume | 16 |
| Issue number | 9 |
| DOIs | |
| State | Published - Oct 1 2016 |
Bibliographical note
Funding Information:This study was supported by the National Natural Science Foundation of China (grant nos. 81472296, 81101867, 81272542, 81200369, 81502275, and 81572992), the China International Medical Foundation (grant no. CIMF-F-H001-057), the Six Major Talent Peak Project of Jiangsu Province (grant no. 2015-WSN-022), the Special Foundation of Clinical Medicine of Jiangsu Provincial Bureau of Science and Technology (grant no. BL2014039), the Scientific Research Project of Jiangsu Provincial Bureau of Traditional Chinese Medicine (grant no. L213236), the Medical Scientific Research Project of Jiangsu Provincial Bureau of Health (grant no. Z201206), the Special Foundation of Wu Jieping Medical Foundation for Clinical Scientific Research (grant nos. 320.6753.1225 and 320.6750.12242), the Science and Education for Health Foundation of Suzhou for Youth (grant nos. SWKQ1003 and SWKQ1011), the Science and Technology Project Foundation of Suzhou (grant nos. SYS201112, SYSD2012137 and SYS201335) and transverse project of Soochow University(grant nos. P112200315 and P112200914).
Publisher Copyright:
© 2016 Bentham Science Publishers.
Keywords
- Dendritic cells
- Fibroblasts
- Macrophages
- Mast cells
- Neural components
- Pancreatic cancer
- Pancreatic stellate cells
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Cancer Research
