TY - JOUR
T1 - The role of the leukemia inhibitory factor receptor in neuroprotective signaling
AU - Davis, Stephanie M.
AU - Pennypacker, Keith R.
N1 - Publisher Copyright:
© 2017
PY - 2018/3
Y1 - 2018/3
N2 - Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
AB - Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
KW - Brain injury
KW - Cytokine
KW - Inflammation
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=85030871298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030871298&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2017.08.008
DO - 10.1016/j.pharmthera.2017.08.008
M3 - Review article
C2 - 28827150
AN - SCOPUS:85030871298
SN - 0163-7258
VL - 183
SP - 50
EP - 57
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
ER -