The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Stephanie M. Davis, Keith R. Pennypacker

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalPharmacology and Therapeutics
Volume183
DOIs
StatePublished - Mar 2018

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • Brain injury
  • Cytokine
  • Inflammation
  • Signal transduction

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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