The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Stephanie M. Davis; Keith R. Pennypacker

doi:10.1016/j.pharmthera.2017.08.008

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Stephanie M. Davis, Keith R. Pennypacker

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Pharmacology and Therapeutics
Volume	183
DOIs	https://doi.org/10.1016/j.pharmthera.2017.08.008
State	Published - Mar 2018

Bibliographical note

Publisher Copyright:
© 2017

Funding

Funding was provided by NINDSR01NS091146.

Funders	Funder number
NINDSR01NS091146
National Institute of Neurological Disorders and Stroke	R01NS091146

Keywords

Brain injury
Cytokine
Inflammation
Signal transduction

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1016/j.pharmthera.2017.08.008

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title = "The role of the leukemia inhibitory factor receptor in neuroprotective signaling",

abstract = "Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.",

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author = "Davis, {Stephanie M.} and Pennypacker, {Keith R.}",

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year = "2018",

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doi = "10.1016/j.pharmthera.2017.08.008",

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AU - Davis, Stephanie M.

AU - Pennypacker, Keith R.

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N2 - Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

AB - Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

KW - Brain injury

KW - Cytokine

KW - Inflammation

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=85030871298&partnerID=8YFLogxK

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U2 - 10.1016/j.pharmthera.2017.08.008

DO - 10.1016/j.pharmthera.2017.08.008

M3 - Review article

C2 - 28827150

AN - SCOPUS:85030871298

SN - 0163-7258

VL - 183

SP - 50

EP - 57

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

ER -

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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