The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Stephanie M. Davis; Keith R. Pennypacker

doi:10.1016/j.pharmthera.2017.08.008

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Stephanie M. Davis, Keith R. Pennypacker

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Pharmacology and Therapeutics
Volume	183
DOIs	https://doi.org/10.1016/j.pharmthera.2017.08.008
State	Published - Mar 2018

Bibliographical note

Funding Information:
Funding was provided by NINDSR01NS091146.

Publisher Copyright:
© 2017

Keywords

Brain injury
Cytokine
Inflammation
Signal transduction

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1016/j.pharmthera.2017.08.008

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title = "The role of the leukemia inhibitory factor receptor in neuroprotective signaling",

abstract = "Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.",

keywords = "Brain injury, Cytokine, Inflammation, Signal transduction",

author = "Davis, {Stephanie M.} and Pennypacker, {Keith R.}",

note = "Funding Information: Funding was provided by NINDSR01NS091146. Publisher Copyright: {\textcopyright} 2017",

year = "2018",

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doi = "10.1016/j.pharmthera.2017.08.008",

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volume = "183",

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AU - Davis, Stephanie M.

AU - Pennypacker, Keith R.

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AB - Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

KW - Brain injury

KW - Cytokine

KW - Inflammation

KW - Signal transduction

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DO - 10.1016/j.pharmthera.2017.08.008

M3 - Review article

C2 - 28827150

AN - SCOPUS:85030871298

VL - 183

SP - 50

EP - 57

ER -

The role of the leukemia inhibitory factor receptor in neuroprotective signaling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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