The role of the spleen in ischemic stroke

Keith R. Pennypacker; Halina Offner

doi:10.1038/jcbfm.2014.212

The role of the spleen in ischemic stroke

Keith R. Pennypacker, Halina Offner

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Original language	English
Pages (from-to)	186-187
Number of pages	2
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	35
Issue number	2
DOIs	https://doi.org/10.1038/jcbfm.2014.212
State	Published - Feb 2 2015

Bibliographical note

Publisher Copyright:
© 2015 ISCBFM All rights reserved.

Keywords

brain ischemia
macrophages
neuroinflammation

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2014.212

Cite this

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title = "The role of the spleen in ischemic stroke",

abstract = "This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.",

keywords = "brain ischemia, macrophages, neuroinflammation",

author = "Pennypacker, {Keith R.} and Halina Offner",

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AU - Pennypacker, Keith R.

AU - Offner, Halina

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KW - macrophages

KW - neuroinflammation

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M3 - Review article

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VL - 35

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EP - 187

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

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ER -

The role of the spleen in ischemic stroke

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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