The role of tumor associated macrophages in the tumor microenvironment: Mechanism and functions

Jie Zhu, Qiaoming Zhi, Binhua P. Zhou, Min Tao, Jingyi Liu, Wei Li

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumor-associated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage’ recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.

Original languageEnglish
Pages (from-to)1133-1141
Number of pages9
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume16
Issue number9
DOIs
StatePublished - Oct 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Bentham Science Publishers.

Keywords

  • Breast cancer
  • Lung cancer
  • Lymphoma
  • Pancreatic cancer
  • Tumor associated macrophages
  • Tumor microenvironment

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research
  • Pharmacology

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