Abstract
The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.
Original language | English |
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Pages (from-to) | 99-109 |
Number of pages | 11 |
Journal | Alzheimer's and Dementia: Translational Research and Clinical Interventions |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2016 |
Bibliographical note
Publisher Copyright:© 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimers Association. This is an open access article under the CC BY-NC-ND license.
Keywords
- Adaptive immunity
- Alzheimer's disease
- Astrocyte
- Innate immunity
- Microglia
- Neuroinflammation
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health