The roles of inflammation and immune mechanisms in Alzheimer's disease

Linda J. Van Eldik; Maria C. Carrillo; Patricia E. Cole; Dominik Feuerbach; Barry D. Greenberg; James A. Hendrix; Matthew Kennedy; Nick Kozauer; Richard A. Margolin; José L. Molinuevo; Reinhold Mueller; Richard M. Ransohoff; Donna M. Wilcock; Lisa Bain; Kelly Bales

doi:10.1016/j.trci.2016.05.001

The roles of inflammation and immune mechanisms in Alzheimer's disease

Linda J. Van Eldik, Maria C. Carrillo, Patricia E. Cole, Dominik Feuerbach, Barry D. Greenberg, James A. Hendrix, Matthew Kennedy, Nick Kozauer, Richard A. Margolin, José L. Molinuevo, Reinhold Mueller, Richard M. Ransohoff, Donna M. Wilcock, Lisa Bain, Kelly Bales

Research output: Contribution to journal › Review article › peer-review

184 Scopus citations

Abstract

The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.

Original language	English
Pages (from-to)	99-109
Number of pages	11
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.trci.2016.05.001
State	Published - Jun 1 2016

Bibliographical note

Publisher Copyright:
© 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimers Association. This is an open access article under the CC BY-NC-ND license.

Funding

For Funding related to the article: L.J.V.E. acknowledges support from NIH R01 NS093920, U01 AG050636, P30 AG028383 and grants from the Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Kentucky Spinal Cord & Head Injury Research Trust (KSCHIRT), and Thome Memorial Foundation. Donna M. Wilcock acknowledges support from NIH R01 NS079637 and P30 AG028383 and a grant from the Alzheimer's Association.

Funders	Funder number
National Institutes of Health (NIH)	P30 AG028383, U01 AG050636, R01 NS093920, R01 NS079637
Alzheimer's Association
Alzheimer's Drug Discovery Foundation
Edward N and Della L Thome Memorial Foundation
Kentucky Spinal Cord and Head Injury Research Trust

Keywords

Adaptive immunity
Alzheimer's disease
Astrocyte
Innate immunity
Microglia
Neuroinflammation

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.trci.2016.05.001

Cite this

Van Eldik, L. J., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B. D., Hendrix, J. A., Kennedy, M., Kozauer, N., Margolin, R. A., Molinuevo, J. L., Mueller, R., Ransohoff, R. M., Wilcock, D. M., Bain, L., & Bales, K. (2016). The roles of inflammation and immune mechanisms in Alzheimer's disease. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 2(2), 99-109. https://doi.org/10.1016/j.trci.2016.05.001

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abstract = "The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.",

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Van Eldik, LJ, Carrillo, MC, Cole, PE, Feuerbach, D, Greenberg, BD, Hendrix, JA, Kennedy, M, Kozauer, N, Margolin, RA, Molinuevo, JL, Mueller, R, Ransohoff, RM, Wilcock, DM, Bain, L & Bales, K 2016, 'The roles of inflammation and immune mechanisms in Alzheimer's disease', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 2, no. 2, pp. 99-109. https://doi.org/10.1016/j.trci.2016.05.001

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AU - Hendrix, James A.

AU - Kennedy, Matthew

AU - Kozauer, Nick

AU - Margolin, Richard A.

AU - Molinuevo, José L.

AU - Mueller, Reinhold

AU - Ransohoff, Richard M.

AU - Wilcock, Donna M.

AU - Bain, Lisa

AU - Bales, Kelly

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AB - The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.

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The roles of inflammation and immune mechanisms in Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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