The RSV F p27 peptide: current knowledge, important questions

Wanderson Rezende; Hadley E. Neal; Rebecca E. Dutch; Pedro A. Piedra

doi:10.3389/fmicb.2023.1219846

The RSV F p27 peptide: current knowledge, important questions

Wanderson Rezende, Hadley E. Neal, Rebecca E. Dutch, Pedro A. Piedra

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.

Original language	English
Article number	1219846
Journal	Frontiers in Microbiology
Volume	14
DOIs	https://doi.org/10.3389/fmicb.2023.1219846
State	Published - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Rezende, Neal, Dutch and Piedra.

Keywords

F protein trimer
cleavage
fusion protein (F)
p27
respiratory syncytial virus (RSV)

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fmicb.2023.1219846

Cite this

@article{4198724e148a41b591f8184430c0fe59,

title = "The RSV F p27 peptide: current knowledge, important questions",

abstract = "Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.",

keywords = "F protein trimer, cleavage, fusion protein (F), p27, respiratory syncytial virus (RSV)",

author = "Wanderson Rezende and Neal, {Hadley E.} and Dutch, {Rebecca E.} and Piedra, {Pedro A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Rezende, Neal, Dutch and Piedra.",

year = "2023",

doi = "10.3389/fmicb.2023.1219846",

language = "English",

volume = "14",

}

TY - JOUR

T1 - The RSV F p27 peptide

T2 - current knowledge, important questions

AU - Rezende, Wanderson

AU - Neal, Hadley E.

AU - Dutch, Rebecca E.

AU - Piedra, Pedro A.

PY - 2023

Y1 - 2023

N2 - Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.

AB - Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.

KW - F protein trimer

KW - cleavage

KW - fusion protein (F)

KW - p27

KW - respiratory syncytial virus (RSV)

UR - http://www.scopus.com/inward/record.url?scp=85164501463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85164501463&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2023.1219846

DO - 10.3389/fmicb.2023.1219846

M3 - Short survey

AN - SCOPUS:85164501463

SN - 1664-302X

VL - 14

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 1219846

ER -

The RSV F p27 peptide: current knowledge, important questions

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this