The RSV F p27 peptide: current knowledge, important questions

Wanderson Rezende, Hadley E. Neal, Rebecca E. Dutch, Pedro A. Piedra

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.

Original languageEnglish
Article number1219846
JournalFrontiers in Microbiology
Volume14
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Rezende, Neal, Dutch and Piedra.

Keywords

  • F protein trimer
  • cleavage
  • fusion protein (F)
  • p27
  • respiratory syncytial virus (RSV)

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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