Abstract
Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.
| Original language | English |
|---|---|
| Article number | 1219846 |
| Journal | Frontiers in Microbiology |
| Volume | 14 |
| DOIs | |
| State | Published - 2023 |
Bibliographical note
Publisher Copyright:Copyright © 2023 Rezende, Neal, Dutch and Piedra.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- F protein trimer
- cleavage
- fusion protein (F)
- p27
- respiratory syncytial virus (RSV)
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
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