The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance

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29 Scopus citations

Abstract

Although cocaine dependence remains a significant public health concern, efforts to identify a pharmacotherapy have been unsuccessful. The purpose of this study was to assess the safety, tolerability, and subject-rated effects of intranasal cocaine during maintenance on aripiprazole, a novel antipsychotic with partial agonist activity at monoamine receptors implicated in the effects of cocaine. To this end, eight cocaine dependent subjects were maintained on 10 mg oral aripiprazole and placebo in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine (4, 20, 40, and 60 mg). Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose.

Original languageEnglish
Pages (from-to)769-776
Number of pages8
JournalAmerican Journal of Drug and Alcohol Abuse
Volume33
Issue number6
DOIs
StatePublished - Nov 2007

Bibliographical note

Funding Information:
This research is supported by NIDA Grant R01 DA 020429 and NCRR Grant M01 RR02602. The authors wish to thank Frances Wagner, RN, Joshua Barnett, John Blackburn, Michelle Gray, Derek Roe, and Kristi Yingling for their expert medical and technical assistance.

Keywords

  • Aripiprazole
  • Cocaine
  • Humans
  • Pharmacotherapy
  • Physiological effects

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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