The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: Increased aripipirazole dose and maintenance period

Joshua A. Lile; William W. Stoops; Lon R. Hays; Craig R. Rush

doi:10.1080/00952990802308262

The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: Increased aripipirazole dose and maintenance period

Joshua A. Lile, William W. Stoops, Lon R. Hays, Craig R. Rush

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.

Original language	English
Pages (from-to)	721-729
Number of pages	9
Journal	American Journal of Drug and Alcohol Abuse
Volume	34
Issue number	6
DOIs	https://doi.org/10.1080/00952990802308262
State	Published - Nov 2008

Bibliographical note

Funding Information:
This research is supported by NIDA grants R01 DA 020429 to Dr. Craig Rush and K01 DA018772 to Dr. Joshua Lile, as well as NCRR Grant M01 RR02602 to Dr. Jay Perman. The authors wish to thank Frances Wagner, R.N., Michelle Gray, Derek Roe, and Kristi Yingling for their expert medical and technical assistance.

Funding

This research is supported by NIDA grants R01 DA 020429 to Dr. Craig Rush and K01 DA018772 to Dr. Joshua Lile, as well as NCRR Grant M01 RR02602 to Dr. Jay Perman. The authors wish to thank Frances Wagner, R.N., Michelle Gray, Derek Roe, and Kristi Yingling for their expert medical and technical assistance.

Funders	Funder number
National Institute on Drug Abuse	K01DA018772, R01 DA 020429
National Institute on Drug Abuse
National Center for Research Resources	M01 RR02602
National Center for Research Resources

Keywords

Aripiprazole
Cocaine
Pharmacotherapy
Physiological effects
Subjective effects

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/00952990802308262

Cite this

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title = "The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: Increased aripipirazole dose and maintenance period",

abstract = "Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.",

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doi = "10.1080/00952990802308262",

language = "English",

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The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: Increased aripipirazole dose and maintenance period. / Lile, Joshua A.; Stoops, William W.; Hays, Lon R. et al.
In: American Journal of Drug and Alcohol Abuse, Vol. 34, No. 6, 11.2008, p. 721-729.

Research output: Contribution to journal › Article › peer-review

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T1 - The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II

T2 - Increased aripipirazole dose and maintenance period

AU - Lile, Joshua A.

AU - Stoops, William W.

AU - Hays, Lon R.

AU - Rush, Craig R.

N1 - Funding Information: This research is supported by NIDA grants R01 DA 020429 to Dr. Craig Rush and K01 DA018772 to Dr. Joshua Lile, as well as NCRR Grant M01 RR02602 to Dr. Jay Perman. The authors wish to thank Frances Wagner, R.N., Michelle Gray, Derek Roe, and Kristi Yingling for their expert medical and technical assistance.

PY - 2008/11

Y1 - 2008/11

N2 - Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.

AB - Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.

KW - Aripiprazole

KW - Cocaine

KW - Pharmacotherapy

KW - Physiological effects

KW - Subjective effects

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The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: Increased aripipirazole dose and maintenance period

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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