Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.
|Number of pages||9|
|Journal||American Journal of Drug and Alcohol Abuse|
|State||Published - Nov 2008|
Bibliographical noteFunding Information:
This research is supported by NIDA grants R01 DA 020429 to Dr. Craig Rush and K01 DA018772 to Dr. Joshua Lile, as well as NCRR Grant M01 RR02602 to Dr. Jay Perman. The authors wish to thank Frances Wagner, R.N., Michelle Gray, Derek Roe, and Kristi Yingling for their expert medical and technical assistance.
- Physiological effects
- Subjective effects
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Clinical Psychology
- Psychiatry and Mental health