The Same CCAAT Box-Binding Factor Binds to the Promoter of Two Coordinately Regulated Major Histocompatibility Complex Class II Genes

M. J. Kern, J. G. Woodward

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Using competition mobility shift, methylation interference, and proteolytic clipping DNA binding assays, we demonstrate that the protein binding the major histocompatibility complex Aβ CCAAT box is indistinguishable from the protein previously named NF-Y, which binds the major histocompatibility complex Eα CCAAT box. Although the two CCAAT boxes share the same 10-base core sequence, termed the Y box, their flanking sequences, known to be important for binding, are very different.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalMolecular and Cellular Biology
Volume11
Issue number1
StatePublished - Jan 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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